Publications
(undergraduate authors, co-first authors# )
72Target-based design of promysalin analogs identifies a new putative binding cleft in succinate dehydrogenase
71Phylogeny-guided Approach Yields Glycopeptides with Unique Action
Cheng, A.V.; Wuest, W.M.*
Trends in Pharmacological Sciences 2020 41, 297 DOI: 10.1016/j.tips.2020.03.002 (Invited Highlight)
70Addition of ethylamines to the phenols of bithionol and synthetic retinoids does not elicit activity in gram-negative bacteria
Cheng, A.V.#; Schrank, C.L.#; Escobar, I.E.; Mylonakis, E.; Wuest, W.M.*
Bioorg. Med. Chem. Lett. 2020 30, 127099 DOI: 10.1016/j.bmcl.2020.127099
68Further Investigations into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics
Leitgeb, A.J.; Feliciano, J.A.; Sanchez, H.; Allen, R.A.; Morrison, K.R.; Sommers, K.J.; Carden, R.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2020 15, 1510 DOI: 10.1002/cmdc.201900662
67Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study
Al-Khalifa, S.; Jennings, M.C.; Granata, D.; Klein, M.; Wuest, W.M.*; Minbiole, K.P.C.*; Carnevale, V.*
ChemBioChem 2020 21, 1510 DOI: 10.1002/cbic.201900698
66Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids
Cheng, A.V.; Kim, W.; Escobar, I.E.; Mylonakis, E.; Wuest, W.M.*
ACS Med. Chem. Lett. 2020 11, 393 DOI: 10.1021/acsmedchemlett.9b00159 (Featured in the Women of Medicinal Chemistry Issue)
65Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms
Le, P.; Kunold, E.; Macsics, R.; Rox, K.; Jennings, M.C.; Ugur, I.; Reinecke, M.; Chaves-Moreno, D.; Hackl, M.W.; Fetzer, C.; Mandl, F.A.M.; Lehmann, J.; Korotkov, V.S.; Hacker, S.M.; Kuster, B.; Antes, I.; Pieper, D.H.; Rohde, M.; Wuest, W.M.; Medina, E.; Sieber, S.A.*
Nature Chemistry 2020 12, 145 DOI: s41557-019-0378-7
64A bisphenolic honokiol analog outcompetes oral antimicrobial agent cetylpyridinium chloride via a membrane-associated mechanism
Ochoa, C.#; Solinski, A.E.#; Nowlan, M.; Dekarske, M.M.; Wuest, W.M.*; Kozlowski, M.C.*
ACS Infectious Diseases 2020 6, 74 DOI: 10.1021/acsinfecdis.9b00190
63A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus
Kim, W.; Zou, G.; Hari, T.P.A.; Wilt, I.K.; Zhu, W.; Galle, N.; Faizi, H.A.; Hendricks, G.L.; Tori. K.; Pan, W.; Huang, X.; Steele, A.D.; Csatary, E.E.; Dekarske, M.M.; Rosen, J.L.; de Queiroz Ribiero, N.; Lee, K.; Port, J.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gao, H.; Ausubel, F.M.; Mylonakis,E.
Proc. Nat. Acad. Sci. 2019 116, 16529 DOI: 10.1073/pnas.1904700116 (Featured on NPR)
62More QACs, more questions: recent advances in structure activity relationships and hurdles in understanding resistance mechanism
Morrison, K.R.; Allen, R.; Minbiole, K.P.C.*; Wuest, W.M.*
Tetrahedron Letters 2019 60, 150935 (Invited Digest) DOI: 10.1016/j.tetlet.2019.07.026
61Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer
Korobeynikov, V.; Borakove, M.; Feng, Y.; Wuest, W.M.; Koval, A.B.; Nikonova, A.S.; Serebriiskii, I.; Chernoff, J.; Borges, V.F.; Golemis, E.A.; Shagisultanova, E.*
Breast Cancer Research & Treatment 2019 117, 369 DOI:10.1007/s10549-019-05329-2
60Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans
Solinski, A.E.; Scharnow, A.M.; Fraboni, A.J., Wuest, W.M.*
ACS Infectious Diseases 2019 5, 1480 DOI:10.1021/acsinfecdis.9b00213
59The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa
Zhao, W.; Cross, A.R.; Crowe-McAuliffe, C.; Weigert-Munoz, A.; Csatary, E.E.; Solinski, A.E.; Krysiak, J.; Goldberg, J.B.; Wilson, D.N.; Medina, E.; Wuest, W.M.; Sieber S.A.*
Angew. Chem. Int. Ed. 2019 58, 8581 DOI: 10.1002/anie.201903472
58Hijacking Bacterial Circuitry of Biofilm Processes via Chemical “Hot-wiring”: An Under-explored Avenue for Therapeutic Development
Wilt, I.K.; Hari, T.P.A.; Wuest, W.M.*
ACS Infectious Diseases 2019 5, 789 DOI: 10.1021/acsinfecdis.9b00104 (Invited Viewpoint)
56Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance
Post, S.J.; Shapiro, J.A.; Wuest, W.M.*
MedChemComm 2019 10, 505 (Invited review for the Antibiotic Resistance Issue) DOI: 10.1039/C9MD000032A
55Targeting S. mutans biofilms: A perspective on preventing dental caries
Scharnow, A.M.; Solinski, A.E.; Wuest, W.M.*
MedChemComm 2019 10 , 1057 (Invited review for the New Talent Collection) DOI: 10.1039/C9MD00015A
54An Investigation into Rigidity-Activity Relationships in bisQAC Amphiphilic Antiseptics
Kontos, R.C.; Schallenhammer, S.A.; Bentley, B.S.; Morrison, K.R.; Feliciano, J.A.; Tasca, J.A.; Kaplan, A.R.; Bezpalko, M.W.; Kassel, S.W.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2019 14, 83 DOI: 10.1002/cmdc.201800622
53Identification of Specific and Non-specific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK)
Shapiro, J.A.; Varga, J.J.; Parsonage, D.; Walton, W.; Redinbo, M.R.; Ross, L.J.; White, E.L.; Bostwick, R.*; Wuest, W.M.*; Clairborne, A.*; Goldberg, J.B.*
ChemMedChem 2019 14, 78 DOI: 10.1002/cmdc.201800652