Publications
(undergraduate authors, co-first authors# )
31Polymeric Quaternary Ammonium Compounds: Versatile Antimicrobial Materials
Zubris, D.L.*; Minbiole, K.P.C.*; Wuest, W.M.*
Current Topics in Medicinal Chemistry 2017 17, 305 DOI: 10.2174/1568026616666160829155805
30Building a Better QAC: Branched Tetracationic Antiseptics
Forman, M.E.; Jennings, M.C.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2016 11, 1401 DOI: 10.1002/cmdc.201600176
29Natural Product-Inspired Approaches to Combat Bacteria
Jennings, M.C.; Wuest, W.M.*
Tetrahedron 2016 72, 3547. DOI: 10.1016/j.tet.2016.04.064 (Editorial Preface for Tetrahedron Symposium-in-Print)
28From Antimicrobial Activity to Mechanism of Resistance: The Multifaceted Role of Simple Quaternary Ammonium Compounds in Bacterial Eradication
Minbiole, K.P.C.*; Jennings, M.C.; Ator, L.E.; Black, J.W.; Grenier, M.C.; LaDow, J.E.; Caran, K.L.; Seifert, K.; Wuest, W.M.*
Tetrahedron 2016 72, 3559. DOI: 10.1016/j.tet.2016.01.014
27Diverted Total Synthesis of Promysalin Analogs Demonstrates that an Iron-Binding Motif is Responsible for its Narrow-spectrum Antibacterial Activity
Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.*
J. Am. Chem. Soc. 2016 138, 5833. DOI: 10.1021/jacs.6b03373
26Structure-Resistance Relationships: Interrogating Antiseptic Resistance in Bacteria with Multicationic Quaternary Ammonium Dyes
Forman, M.E.; Fletcher, M.H.; Jennings, M.C.; Duggan, S.M.; Minbiole, K.P.C.*; Wuest, W.M.
ChemMedChem 2016 11, 958.DOI: 10.1002/cmdc.201600095
25The Enantioselective Synthesis and Biological Evaluation of Chimeric Promysalin Analogs Facilitated by Diverted Total Synthesis
Knouse, K.W.; Wuest, W.M
J. Antibiotics 2016 69, 337. DOI: 10.1038/ja.2016.4 (invited paper for Amos B. Smith, III issue)
24Natural Product-Derived Quaternary Ammonium Compounds with Potent Antimicrobial Activity
Joyce, M.D.; Jennings, M.C.; Santiago, C.N.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.*
.Antibiotics 2016 69, 344. DOI: 10.1038/ja.2015.107 (invited paper for A.B. Smith, III issue)
22The rhizosphere microbiome: A playground for natural product chemists
Keohane, C.E.; Steele, A.D.; Wuest, W.M.*
Synlett 2015 26, 2739. DOI: 10.1055/s-0035-1560711 (invited Synpact Paper)
21Scaffold-hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials
Mitchell, M.A.; Iannetta, A.A.; Jennings, M.C.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemBioChem 2015 16, 2299. DOI: 10.1002/cbic.201500381
20Total Synthesis and Biological Evaluation of (-)-Promysalin
Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.*
J. Am. Chem. Soc. 2015 137, 7314. DOI: 10.1021/jacs.5b04767
19Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance
Jennings, M.C.; Minbiole, K.P.C.; Wuest, W.M.*
ACS Infectious Diseases, 2015 1, 288
18Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus
Jennings, M.C.; Buttaro, B.A.; Minbiole, K.P.C.; Wuest, W.M.*
ACS Infectious Diseases, 2015 1, 304. DOI: 10.1021/acsinfecdis.5b00032
17Molecular Simulation of Conformational Pre-organization in Cyclic RGD Peptides
Wakefield, A.E.; Wuest, W.M.; Voelz, V.A.
J. Chem. Inf. Model, 2015 55, 806. DOI: 10.1021/ci500768u
16The antimicrobial activity of mono-, bis-, tris-, and tetracationic amphiphiles derived from simple polyamine platforms.
Paniak, T.J.; Jennings, M.C.; Shanahan, P.C.; Joyce, M.D.; Santiago, C.N.; Wuest, W.M.*; Minbiole, K.P.C.*
Bioorg. Med. Chem. Lett. 2014 24, 5824.
15Synthesis of cyclic dimeric methyl morpholinoside – a common synthetic precursor to cyclic dinucleotide analogs.
Kinzie, C.R.; Steele, A.D.; Pasciolla, S.M.; Wuest, W.M.*
Tetrahedron Lett. 2014 55, 4966. DOI: 10.1016/j.tetlet.2014.07.038
14Beyond paraquats: Dialkyl 3,3′- and 3,4′-bipyridinium amphiphiles as antibacterial agents
Ator, L.C.; Jennings, M.C.; McGettigan, A.R.; Paul, J.J.; Wuest, W.M.*; Minbiole, K.P.C.
Bioorg. Med. Chem. Lett. 2014 24, 3706. DOI: 10.1016/j.bmcl.2014.07.024
13Biofilm Eradicating Properties of Quaternary Ammonium Amphiphiles: Simple Mimics of Antimicrobial Peptides
Jennings, M.C.; Ator, L.C.; Paniak, T.J.; Minbiole, K.P.C.*; Wuest, W.M.*
ChemBioChem 2014 15, 2211. DOI: 10.1002/cbic.201402254
12Draining the moat: Disrupting bacterial biofilms with natural products
Fletcher, M.H.; Jennings, M.C.; Wuest, W.M.
Tetrahedron 2014 70, 6373. DOI: 10.1016/j.tet.2014.06.055 (invited review)