Publications
(undergraduate authors, co-first authors# )
126Highly Effective Biocides against Pseudomonas aeruginosa Reveal New Mechanistic Insights Across Gram-Negative Bacteria
123In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe
Amber M. Scharnow, Amy E. Solinski, Sebastian Rowe, Ines Drechsel, Hua Zhang, Elana Shaw, Julia E. Page, Hui Wu, Stephan A. Sieber, William M. Wuest*
J. Am. Chem. Soc. 2024, 146, 33, 23449–23456
94Antibacterials
Cheng, A. V.; Wuest, W.M.
2021 DOI: 10.1021/acs.infocus.7e4006 (Invited contributor for ACS In-Focus Series of E-books)
85Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumannii via Dysregulation of Heme Biosynthesis
Hubner, I.; Shapiro, J.A.; Hobmann, J.; Drechsel, J.; Hacker, S.M.; Rather, P.N.; Piepar, D.H.; Wuest, W.M.; Sieber, S.A.
ACS Central Science 2021 7, 488 DOI: 10.1021/acscentralsci.0c01621
76Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?
Schrank, C.L.; Minbiole, K.P.C.*; Wuest, W.M.*
ACS Infectious Diseases 2020 6, 1553 DOI: 10.1021/acsinfecdis.0c00265
65Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms
Le, P.; Kunold, E.; Macsics, R.; Rox, K.; Jennings, M.C.; Ugur, I.; Reinecke, M.; Chaves-Moreno, D.; Hackl, M.W.; Fetzer, C.; Mandl, F.A.M.; Lehmann, J.; Korotkov, V.S.; Hacker, S.M.; Kuster, B.; Antes, I.; Pieper, D.H.; Rohde, M.; Wuest, W.M.; Medina, E.; Sieber, S.A.*
Nature Chemistry 2020 12, 145 DOI: s41557-019-0378-7
63A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus
Kim, W.; Zou, G.; Hari, T.P.A.; Wilt, I.K.; Zhu, W.; Galle, N.; Faizi, H.A.; Hendricks, G.L.; Tori. K.; Pan, W.; Huang, X.; Steele, A.D.; Csatary, E.E.; Dekarske, M.M.; Rosen, J.L.; de Queiroz Ribiero, N.; Lee, K.; Port, J.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gao, H.; Ausubel, F.M.; Mylonakis,E.
Proc. Nat. Acad. Sci. 2019 116, 16529 DOI: 10.1073/pnas.1904700116 (Featured on NPR)
59The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa
Zhao, W.; Cross, A.R.; Crowe-McAuliffe, C.; Weigert-Munoz, A.; Csatary, E.E.; Solinski, A.E.; Krysiak, J.; Goldberg, J.B.; Wilson, D.N.; Medina, E.; Wuest, W.M.; Sieber S.A.*
Angew. Chem. Int. Ed. 2019 58, 8581 DOI: 10.1002/anie.201903472
46A new class of synthetic retinoid antibiotics effective against bacterial persisters
Kim, W.; Zhu, W.; Hendricks, G.L.; Van Tyne, D.; Steele, A.D.; Keohane, C.E.; Fricke, N.; Conery, A.L.; Shen, S.; Pan, W.; Lee, K.; Rajamuthiah, R.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gilmore, M.S.; Gao, H.; Ausubel, F.M.; Mylonakis, E.
Nature 2018 556, 103. DOI: 10.1038/nature26157
43Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action
Steele, A.D.; Ernouf, G.; Lee, Y-E.; Wuest, W.M.*
Organic Letters 2018 20, 1126 DOI: 10.1021/acs.orglett.8b00054
42Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase
Keohane, C.E.; Steele, A.D.; Fetzer, C.; Khowsathit, J.; Van Tyne, D.; Moynie, L.; Gilmore, M.S.; Karanicolas, J.; Sieber, S.A.; Wuest, W.M.*
J. Am. Chem. Soc. 2018 140, 1774 DOI: 10.1021/jacs.7b11212
38Natural Products as Platforms to Overcome Antibiotic Resistance
Rossiter, S.E.; Fletcher, M.H.; Wuest, W.M.*
Chemical Reviews 2017 117, 12415 DOI: 10.1021/acs.chemrev.7b00283
35Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms
Solinski, A.E.#; Koval, A.B.#; Brzozowski, R.S.#; Morrison, K.R.; Fraboni, A.J.; Carson, C.E.; Eshraghi A.R.; Zhou, G.; Quivey, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest. W.M.*
J. Am. Chem. Soc. 2017 139, 7188. DOI: 10.1021/jacs.7b03879
27Diverted Total Synthesis of Promysalin Analogs Demonstrates that an Iron-Binding Motif is Responsible for its Narrow-spectrum Antibacterial Activity
Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.*
J. Am. Chem. Soc. 2016 138, 5833. DOI: 10.1021/jacs.6b03373
20Total Synthesis and Biological Evaluation of (-)-Promysalin
Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.*
J. Am. Chem. Soc. 2015 137, 7314. DOI: 10.1021/jacs.5b04767
19Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance
Jennings, M.C.; Minbiole, K.P.C.; Wuest, W.M.*
ACS Infectious Diseases, 2015 1, 288
18Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus
Jennings, M.C.; Buttaro, B.A.; Minbiole, K.P.C.; Wuest, W.M.*
ACS Infectious Diseases, 2015 1, 304. DOI: 10.1021/acsinfecdis.5b00032