Publications
(undergraduate authors, co-first authors# )
52From General to Specific: Can Primary Metabolism in Pseudomonas be Exploited for Narrow-Spectrum Antibiotics?
51Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space
Kearney, S.E.; Zahoransky-Kohalmi, G.; et al.
ACS Central Science 2018 4, 1727 DOI: 10.1021/acscentsci.8b00747
50Epoxy isonitriles, a unique class of antibiotics – Synthesis of their metabolites and biological investigations
Ernouf, G.; Wilt, I.K.; Zahim, S.; Wuest, W.M.*
ChemBioChem 2018 19, 2448 (Selected for ChemBio Talents Issue) DOI: 10.1002/cbic
49Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product
Shapiro, J.A.#; Morrison, K.R.#; Chodisetty, S.S.; Musaev, D.G.; Wuest, W.M.*
Org. Lett. 2018 20, 5922. DOI: 10.1021/acs.orglett.8b02599
48Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters
Kim, W.; Steele, A.D.; Zhu, W.; Csatary, E.E.; Fricke, N.; Dekarske, M.M.; Jayamani, E.; Pan, W.; Kwon, B.; Sinitsa, I.F.; Rosen, J.; Conery, A.L.; Fuchs, B.B.; Vlahovska, P.M.; Ausubel, F.M.; Gao, H.; Wuest, W.M.*; Mylonakis, E.
ACS Infectious Diseases 2018 4, 1540 DOI: 10.1021/acsinfecdis.8b00161
47Transcriptomic profiling suggest that Promysalin alters metabolic flux, motility, and iron regulation in Pseudomonas putida KT2440
Giglio, K.; Keohane, C.E.; Stodghill, P.; Steele, A.D.; Fetzer, C.; Sieber, S.A.; Filiatrault, M.J.*; Wuest, W.M.*
ACS Infectious Diseases 2018 4, 1179. DOI: 10.1021/acsinfecdis.8b00041
46A new class of synthetic retinoid antibiotics effective against bacterial persisters
Kim, W.; Zhu, W.; Hendricks, G.L.; Van Tyne, D.; Steele, A.D.; Keohane, C.E.; Fricke, N.; Conery, A.L.; Shen, S.; Pan, W.; Lee, K.; Rajamuthiah, R.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gilmore, M.S.; Gao, H.; Ausubel, F.M.; Mylonakis, E.
Nature 2018 556, 103. DOI: 10.1038/nature26157
45Claramines: A new class of broad-spectrum antimicrobial agents with bimodal activity
Blanchet, M.; Borselli, D.; Rodallec, A.; Peiretti, F.; Vidal, N.; Bolla, J.M.; Digiorgio, C.; Morrison, K.R.; Wuest, W.M.; Brunel, J.M*
ChemMedChem 2018 13, 1018 DOI: 10.1002/cmdc.201800073
44A dual inhibitor of Staphylococcus aureus virulence and biofilm attenuates expression of major toxins and adhesins
Hofbauer, B.; Vomacka, J.; Stahl, M.; Korotkov, V.; Jennings, M.C.; Wuest, W.M.; Sieber, S.A.*
Biochemistry 2018 57, 1814. DOI: 10.1021/acs.biochem.7b01271
43Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action
Steele, A.D.; Ernouf, G.; Lee, Y-E.; Wuest, W.M.*
Organic Letters 2018 20, 1126 DOI: 10.1021/acs.orglett.8b00054
42Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase
Keohane, C.E.; Steele, A.D.; Fetzer, C.; Khowsathit, J.; Van Tyne, D.; Moynie, L.; Gilmore, M.S.; Karanicolas, J.; Sieber, S.A.; Wuest, W.M.*
J. Am. Chem. Soc. 2018 140, 1774 DOI: 10.1021/jacs.7b11212
41Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria
Solinski, A.E.#; Ochoa, C.#; Lee, Y-E.; Paniak, T.; Kozlowski, M.C.*; Wuest, W.M.*
ACS Infectious Diseases 2018 4, 118 DOI:10.1021/acsinfecdis.7b00178
40Hybrid BisQACs: Potent Biscationic Quaternary Ammonium Compounds Merging the Structures of Two Commercial Antiseptics
Schallenhammer, S.A.; Duggan, S.M.; Morrison, K.R.; Bentley, B.S.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2017 12, 1931 DOI: 10.1002/cmdc.201700597
39ErosS enzyme from Aliivibrio fischeri plays Cupid to choanoflagellates
Rossiter, S.E.; Wuest, W.M.*
ChemBioChem 2017 18, 2298 DOI: 10.1002/cbic.201700552 (Invited Highlight)
38Natural Products as Platforms to Overcome Antibiotic Resistance
Rossiter, S.E.; Fletcher, M.H.; Wuest, W.M.*
Chemical Reviews 2017 117, 12415 DOI: 10.1021/acs.chemrev.7b00283
37Efflux Pumps May Not Be the Major Drivers of QAC Resistance in Methicillin-Resistant Staphylococcus aureus
Jennings, M.C.; Forman, M.E.; Duggan, S.M.; Minbiole, K.P.C.*; Wuest, W.M.*
ChemBioChem 2017 18, 1573 DOI: 10.1002/cbic.201700233 (highlighted as a Very Important Paper, Selected as Cover Art)
36A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method
Fletcher, M.H.; Burns-Lynch, C.E.; Knouse, K.W.; Abraham, L.T.; DeBrosse, C.W.; Wuest, W.M.*
RSC Adv. 2017 7, 29835. DOI: 10.1039/C7RA06045A
35Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms
Solinski, A.E.#; Koval, A.B.#; Brzozowski, R.S.#; Morrison, K.R.; Fraboni, A.J.; Carson, C.E.; Eshraghi A.R.; Zhou, G.; Quivey, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest. W.M.*
J. Am. Chem. Soc. 2017 139, 7188. DOI: 10.1021/jacs.7b03879
34Ester- and Amide-containing MultiQACs: Exploring Multicationic Soft Antimicrobial Agents
Allen, R.A.; Jennings, M.C.; Mitchell, M.A.; Al-Khalifa, S.E.; Wuest, W.M.*; Minbiole, K.P.C.*
Bioorg. Med. Chem. Lett. 2017 27, 2107. DOI: 10.1016/j.bmcl.2017.03.077
33Twelve-Membered Macrolactones: Privileged Scaffolds for the Development of New Therapeutics
Brzozowski, R.S.; Wuest, W.M.*
Chemical Biology & Drug Design 2017 89, 169 (invited review) DOI: 10.1111/cbdd.12783