Publications
(undergraduate authors, co-first authors# )
133Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship Between Self-assembly and Cytolytic Activity
123In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe
Amber M. Scharnow, Amy E. Solinski, Sebastian Rowe, Ines Drechsel, Hua Zhang, Elana Shaw, Julia E. Page, Hui Wu, Stephan A. Sieber, William M. Wuest*
J. Am. Chem. Soc. 2024, 146, 33, 23449–23456
110Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection
Huang, X.; Pan, W.; Zhong, M-Z.; Chhonker. Y.S.; Steele, A.D.; Keohane, C.E.; Mishra, B.; Lucas, O.F.R.; Murry. D.J.; Ausubel, F.M.; Wuest. W.M.; Li, C-X.; Mylonakis. E.*
Antimicrobial Agents and Chemotherapy 2023 67, e10679-22 DOI: 10.1128/aac.01679-22
95Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles to Evade Disinfectant Resistance
Sommers, K.J.#; Michaud, M.E.#; Hogue, C.E.; Scharnow, A.M.; Amoo, L.E.; Peterson, A.A.; Carden, R.G.; Minbiole, K.P.C.*; Wuest. W.M.*
ACS Infectious Diseases 2022 8, 387. DOI: 10.1021/acsinfecdis.1c00611
85Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumannii via Dysregulation of Heme Biosynthesis
Hubner, I.; Shapiro, J.A.; Hobmann, J.; Drechsel, J.; Hacker, S.M.; Rather, P.N.; Piepar, D.H.; Wuest, W.M.; Sieber, S.A.
ACS Central Science 2021 7, 488 DOI: 10.1021/acscentralsci.0c01621
67Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study
Al-Khalifa, S.; Jennings, M.C.; Granata, D.; Klein, M.; Wuest, W.M.*; Minbiole, K.P.C.*; Carnevale, V.*
ChemBioChem 2020 21, 1510 DOI: 10.1002/cbic.201900698
65Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms
Le, P.; Kunold, E.; Macsics, R.; Rox, K.; Jennings, M.C.; Ugur, I.; Reinecke, M.; Chaves-Moreno, D.; Hackl, M.W.; Fetzer, C.; Mandl, F.A.M.; Lehmann, J.; Korotkov, V.S.; Hacker, S.M.; Kuster, B.; Antes, I.; Pieper, D.H.; Rohde, M.; Wuest, W.M.; Medina, E.; Sieber, S.A.*
Nature Chemistry 2020 12, 145 DOI: s41557-019-0378-7
63A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus
Kim, W.; Zou, G.; Hari, T.P.A.; Wilt, I.K.; Zhu, W.; Galle, N.; Faizi, H.A.; Hendricks, G.L.; Tori. K.; Pan, W.; Huang, X.; Steele, A.D.; Csatary, E.E.; Dekarske, M.M.; Rosen, J.L.; de Queiroz Ribiero, N.; Lee, K.; Port, J.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gao, H.; Ausubel, F.M.; Mylonakis,E.
Proc. Nat. Acad. Sci. 2019 116, 16529 DOI: 10.1073/pnas.1904700116 (Featured on NPR)
60Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans
Solinski, A.E.; Scharnow, A.M.; Fraboni, A.J., Wuest, W.M.*
ACS Infectious Diseases 2019 5, 1480 DOI:10.1021/acsinfecdis.9b00213
59The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa
Zhao, W.; Cross, A.R.; Crowe-McAuliffe, C.; Weigert-Munoz, A.; Csatary, E.E.; Solinski, A.E.; Krysiak, J.; Goldberg, J.B.; Wilson, D.N.; Medina, E.; Wuest, W.M.; Sieber S.A.*
Angew. Chem. Int. Ed. 2019 58, 8581 DOI: 10.1002/anie.201903472
54An Investigation into Rigidity-Activity Relationships in bisQAC Amphiphilic Antiseptics
Kontos, R.C.; Schallenhammer, S.A.; Bentley, B.S.; Morrison, K.R.; Feliciano, J.A.; Tasca, J.A.; Kaplan, A.R.; Bezpalko, M.W.; Kassel, S.W.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2019 14, 83 DOI: 10.1002/cmdc.201800622
53Identification of Specific and Non-specific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK)
Shapiro, J.A.; Varga, J.J.; Parsonage, D.; Walton, W.; Redinbo, M.R.; Ross, L.J.; White, E.L.; Bostwick, R.*; Wuest, W.M.*; Clairborne, A.*; Goldberg, J.B.*
ChemMedChem 2019 14, 78 DOI: 10.1002/cmdc.201800652
51Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space
Kearney, S.E.; Zahoransky-Kohalmi, G.; et al.
ACS Central Science 2018 4, 1727 DOI: 10.1021/acscentsci.8b00747
50Epoxy isonitriles, a unique class of antibiotics – Synthesis of their metabolites and biological investigations
Ernouf, G.; Wilt, I.K.; Zahim, S.; Wuest, W.M.*
ChemBioChem 2018 19, 2448 (Selected for ChemBio Talents Issue) DOI: 10.1002/cbic
48Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters
Kim, W.; Steele, A.D.; Zhu, W.; Csatary, E.E.; Fricke, N.; Dekarske, M.M.; Jayamani, E.; Pan, W.; Kwon, B.; Sinitsa, I.F.; Rosen, J.; Conery, A.L.; Fuchs, B.B.; Vlahovska, P.M.; Ausubel, F.M.; Gao, H.; Wuest, W.M.*; Mylonakis, E.
ACS Infectious Diseases 2018 4, 1540 DOI: 10.1021/acsinfecdis.8b00161
47Transcriptomic profiling suggest that Promysalin alters metabolic flux, motility, and iron regulation in Pseudomonas putida KT2440
Giglio, K.; Keohane, C.E.; Stodghill, P.; Steele, A.D.; Fetzer, C.; Sieber, S.A.; Filiatrault, M.J.*; Wuest, W.M.*
ACS Infectious Diseases 2018 4, 1179. DOI: 10.1021/acsinfecdis.8b00041
46A new class of synthetic retinoid antibiotics effective against bacterial persisters
Kim, W.; Zhu, W.; Hendricks, G.L.; Van Tyne, D.; Steele, A.D.; Keohane, C.E.; Fricke, N.; Conery, A.L.; Shen, S.; Pan, W.; Lee, K.; Rajamuthiah, R.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gilmore, M.S.; Gao, H.; Ausubel, F.M.; Mylonakis, E.
Nature 2018 556, 103. DOI: 10.1038/nature26157
45Claramines: A new class of broad-spectrum antimicrobial agents with bimodal activity
Blanchet, M.; Borselli, D.; Rodallec, A.; Peiretti, F.; Vidal, N.; Bolla, J.M.; Digiorgio, C.; Morrison, K.R.; Wuest, W.M.; Brunel, J.M*
ChemMedChem 2018 13, 1018 DOI: 10.1002/cmdc.201800073
44A dual inhibitor of Staphylococcus aureus virulence and biofilm attenuates expression of major toxins and adhesins
Hofbauer, B.; Vomacka, J.; Stahl, M.; Korotkov, V.; Jennings, M.C.; Wuest, W.M.; Sieber, S.A.*
Biochemistry 2018 57, 1814. DOI: 10.1021/acs.biochem.7b01271
42Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase
Keohane, C.E.; Steele, A.D.; Fetzer, C.; Khowsathit, J.; Van Tyne, D.; Moynie, L.; Gilmore, M.S.; Karanicolas, J.; Sieber, S.A.; Wuest, W.M.*
J. Am. Chem. Soc. 2018 140, 1774 DOI: 10.1021/jacs.7b11212