Publications
(undergraduate authors, co-first authors# )
128Leveraging Natural Product-Inspired Antifungals to Investigate the Mechanism of Action of Peniciaculin A
125Bushy-Tailed QACs: The Development of Multicationic Quaternary Ammonium Compounds with a High Degree of Alkyl Chain Substitution
Zachary E. A. Toles, Dr. Laura M. Thierer, Alice Wu, Elise L. Bezold, Dr. Diana Rachii, Christian A. Sanchez, Germán G. Vargas-Cuebas, Dr. Taylor M. Keller, Dr. Patrick J. Carroll, Prof. William M. Wuest, Prof. Kevin P. C. Minbiole
ChemMedChem 2024, 19, e202400301
120Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures
Moneya S. Leatherbury, Dr. Laura M. Thierer, Christian A. Sanchez, Germán G. Vargas-Cuebas, Ashley A. Petersen, Lauren E. Amoo, Elise L. Bezold, Keshyne C. Washington, M. Brody Mistrot, Michael J. Zdilla, Prof. William M. Wuest, Prof. Kevin P. C. Minbiole
ChemMedChem, 2024, 19, e202300718.
117Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C
Ryan A Allen, Caroline EM McCormack, William M Wuest
ChemMedChem, 2023, 18, e202300253.
115A versatile strategy for the synthesis of various lumazine peptides
Zhang, W., Mahoney, A.R., Garrison, M., Wuest, W.M.*
Med Chem Res 32, 1481–1496 (2023). https://doi.org/10.1007/s00044-023-03097-9
112Antimicrobial activity of a new class of synthetic retinoid antibiotics and comparator agents against ocular staphylococci
Andre, C.; Schrank, C.L.; Cheng, A.V.; Mylonakis, E.; Wuest, W.M.; Gilmore, M.S.; Kim. W.; Bispo, P.J.M.*
Frontiers in Antibiotics 2023 2, 1101450 DOI: 10.3389/frabi.2023.1101450
111Structure-based Design of Promysalin Analogues to Overcome Mechanisms of Bacterial Resistance
Mahoney, A.R.; Storek, K.M.; Wuest, W.M.*
ACS Omega 2023 8, 12558-12564. DOI: 10.1021/acsomega.3c00884
109Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition.
Kavanaugh. L.G.#; Mahoney, A.R.#; Dey, D.; Wuest, W.M.*; Conn, G.L.
npj Antimicrob Resist 1, 12 (2023). https://doi.org/10.1038/s44259-023-00013-4
108Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents
Brayton, S.R.; Toles, Z.E.A.; Sanchez, C.A.; Michaud, M.E.; Thierer L.M.; Keller, T.M.; Risener, C.J.; Quave, C.L.; Wuest, W.M.*; Minbiole, K.P.C.*
ACS Infectious Diseases 2023 9, 943-951. DOI: 10.1021/acsinfecdis.2c00624
107Double BAC and Triple BAC: A Systematic Analysis of the Disinfectant Properties of Multicationic Derivatives of Benzylalkonium Chloride (BAC)
Toles, Z.E.A.; Wu, A.; Sanchez, C.A.; Michaud, M.E.; Thierer, L.M.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2023 18, e202300018 DOI: 10.1002/cmdc.202300018
105Atom Economical QPCs: Phenyl-free Biscationic Quaternary Phosphonium Compounds as Potent Disinfectants
Thierer, L.M.; Peterson, A.A.; Michaud, M.E.; Sanchez, C.A.; Brayton, S.; Wuest, W.M.*; Minbiole, K.P.C.*
ACS Infectious Diseases 2023 9, 609-616. DOI: 10.1021/acsinfecdis.2c00575
98Rigidity-Activity Relationships of bisQPC Scaffolds against Pathogenic Bacteria
Spahr, A.C.; Michaud, M.E.; Amoo, L.E.; Sanchez, C.A.; Hogue, C. E.; Thierer, L.M.; Gau, M.R.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2022 17, e202200224. DOI: 10.1002/cmdc.202200224
97Exploration of inhibitors of the bacterial LexA repressor-protease
Cheng, A.V.C.#; Cory, M.B.#; Li, A.; Kohli, R.M.*; Wuest, W.M.*
Bioorg. Med. Chem. Lett. 2022 65, 128702. DOI: 10.1016/j.bmcl.2022.128702
96nTZDpa (non-thiazolidinedione PPARγ partial agonist) derivatives retain antimicrobial activity without improving renal toxicity
Dekarske, M.M.; Felix, L.O.; Ortiz, C.O.; Csatary, E.E.; Mylonakis, E.; Wuest, W.M.*
Bioorg. Med. Chem. Lett. 2022 64, 128678. DOI: 10.1016/j.bmcl.2022.128678
91Promiscuous Pseudomonas: Uptake of non-endogenous ligands for iron acquisition
Kaplan, A.R.; Wuest, W.M.*
Tetrahedron Letters 2021 75, 153204 DOI: 10.1016/j.tetlet.2021.153204 (Tetrahedron Special Issue honoring Dale Boger)
87Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonas Demonstrating Siderophore-like Activity
Kaplan, A.R.; Musaev, D.G.; Wuest, W.M.*
ACS Infectious Diseases 2021 7, 544 DOI: 10.1021/acsinfecdis.0c00897
86Trivalent Sulfonium Compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles
Feliciano, J.A.; Leitgeb, A.J.; Schrank, C.L.; Allen, R.A.; Wuest, W.M.*; Minbiole, K.P.C.*; Carden, R.G.*
Bioorg. Med. Chem. Lett. 2021 37, 127809 DOI: 10.1016/j.bmcl.2021.127809
82Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures
Sommers, K.J.; Bentley, B.S.; Carden, R.G.; Post, S.J.; Allen, R.A.; Kontos, R.C.; Black, J.W.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2021 16, 467 DOI: 10.1002/cmdc.20200605
73Broadening Activity of Polymyxin by Quaternary Ammonium Grafting
Ongwae, G.; Morrison, K.R.; Allen, R.A.; Kim, S.; Im, W.; Wuest, W.M.; Pires, M.M.*
ACS Infectious Diseases 2020 6, 1427 DOI: 10.1021/acsinfecdis.0c00037 (Antibiotics Special Issue)