Publications
(undergraduate authors, co-first authors# )
132Not all disinfectants are created equal: the importance of mechanistic understanding to drive research forward
131From Natural Products to Small Molecules: Recent Advancements in Anti-MRSA Therapeutics
Jacqueline R. Smith, Andrew R. LeBlanc, William M. Wuest*
ACS Med. Chem. Lett. 2025, ASAP
130Microbial Changes Occurring During Oronasal Fistula Wound Healing
Steven L. Goudy*, Heath L. Bradley, Camilo Anthony Gacasan, Afra Toma, Keerthi Priya Chinniampalayam Sekar, William M. Wuest, Martin Tomov, Vahid Serpooshan, Ahmet Coskun and Rheinallt M. Jones
Microorganisms 2025, 13(2), 327
129Recent developments in antimicrobial small molecule quaternary phosphonium compounds (QPCs) – synthesis and biological insights
Diana McDonough, Christian A. Sanchez, William M. Wuest* and Kevin P. C. Minbiole
RSC Medicinal Chemistry., 2025, Advance Article
128Leveraging Natural Product-Inspired Antifungals to Investigate the Mechanism of Action of Peniciaculin A
Dr. Ingrid K. Wilt, Dr. Adrian R. Demeritte, Alexander T. Kim, Dr. Weiwei Wang, Prof. Dr. William M. Wuest
ChemMedChem, 2024, 19, e202400500
127Adaptations to cationic biocide exposure differentially influence virulence factors and pathogenicity in Pseudomonas aeruginosa
Germán G Vargas-Cuebas, Christian A Sanchez, Elise L Bezold, Gabrielle M Walker, Shehreen Siddiqui, Kevin PC Minbiole, William M Wuest
Virulence, 2024, 15, 2397503.
126Highly Effective Biocides against Pseudomonas aeruginosa Reveal New Mechanistic Insights Across Gram-Negative Bacteria
Christian A Sanchez, Germán G Vargas-Cuebas, Marina E Michaud, Ryan A Allen, Kelly R Morrison-Lewis, Shehreen Siddiqui, Kevin PC Minbiole, William M Wuest
ACS Infect. Dis. 2024, 10, 11, 3868–3879
125Bushy-Tailed QACs: The Development of Multicationic Quaternary Ammonium Compounds with a High Degree of Alkyl Chain Substitution
Zachary E. A. Toles, Dr. Laura M. Thierer, Alice Wu, Elise L. Bezold, Dr. Diana Rachii, Christian A. Sanchez, Germán G. Vargas-Cuebas, Dr. Taylor M. Keller, Dr. Patrick J. Carroll, Prof. William M. Wuest, Prof. Kevin P. C. Minbiole
ChemMedChem 2024, 19, e202400301
124Exploring the Correlation of Dynamic Surface Tension with Antimicrobial Activities of Quaternary Ammonium-Based Disinfectants
Germán G. Vargas-Cuebas, Dr. Christian A. Sanchez, Samantha R. Brayton, Alexander Nikoloff, Dr. Ronald Masters, Prof. Kevin P. C. Minbiole, Prof. William M. Wuest
ChemMedChem, 2024, 19, e202400262
123In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe
Amber M. Scharnow, Amy E. Solinski, Sebastian Rowe, Ines Drechsel, Hua Zhang, Elana Shaw, Julia E. Page, Hui Wu, Stephan A. Sieber, William M. Wuest*
J. Am. Chem. Soc. 2024, 146, 33, 23449–23456
122Siderophores: A Case Study in Translational Chemical Biology
Andrew R. LeBlanc and William M. Wuest.
Published as part of Biochemistry virtual special issue “A Tribute to Christopher T. Walsh”.
Biochemistry, 2024, 63, 1877
121Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation
Carter U. Brzezinski, Andrew R. LeBlanc, Madeline G. Clerici, and William M. Wuest*
Org. Lett., 2024, 26, 5534
120Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures
Moneya S. Leatherbury, Dr. Laura M. Thierer, Christian A. Sanchez, Germán G. Vargas-Cuebas, Ashley A. Petersen, Lauren E. Amoo, Elise L. Bezold, Keshyne C. Washington, M. Brody Mistrot, Michael J. Zdilla, Prof. William M. Wuest, Prof. Kevin P. C. Minbiole
ChemMedChem, 2024, 19, e202300718.
119Metal chelation as an antibacterial strategy for Pseudomonas aeruginosa and Acinetobacter baumannii
Martina M. Golden a, Amelia C. Heppe a, Cassandra L. Zaremba *c and William M. Wuest
RSC Chem. Biol., 2024, 5, 1083
118Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold
Justin A Shapiro, Savannah J Post, Gavin C Smith, William M Wuest
Org. Lett. 2023, 25, 51, 9243–9248
117Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C
Ryan A Allen, Caroline EM McCormack, William M Wuest
ChemMedChem, 2023, 18, e202300253.
116Investigating the Role of Metabolism for Antibiotic Combination Therapies in Pseudomonas aeruginosa
MM Golden, SJ Post, R Rivera, WM Wuest
ACS Infectious Diseases 9 (12), 2386-2393
115A versatile strategy for the synthesis of various lumazine peptides
Zhang, W., Mahoney, A.R., Garrison, M., Wuest, W.M.*
Med Chem Res 32, 1481–1496 (2023). https://doi.org/10.1007/s00044-023-03097-9
114Total synthesis and biological investigation of mindapyrroles A and B
Allen, R.; Wuest, W.M.*
ChemMedChem 2023 e202300235 DOI: 10.1002/cmdc.202300235 (Highlighted as a Very Important Paper)
113Visible-Light/Nickel-Catalyzed Carboxylation of C(sp2) Bromides via Formate Activation
Smith, G.C.; Zhang, D.H.; Zhang, W.; Soliven, A.H.; Wuest, W.M.*
J. Org. Chem. 2023 ASAP DOI: 10.1021/acs.joc.3c00895