Publications

(undergraduate authors, co-first authors# )

35Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms

Solinski, A.E.#; Koval, A.B.#; Brzozowski, R.S.#; Morrison, K.R.; Fraboni, A.J.; Carson, C.E.; Eshraghi A.R.; Zhou, G.; Quivey, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest. W.M.*   J. Am. Chem. Soc. 2017 139, 7188. DOI: 10.1021/jacs.7b03879

34Ester- and Amide-containing MultiQACs: Exploring Multicationic Soft Antimicrobial Agents

Allen, R.A.; Jennings, M.C.; Mitchell, M.A.; Al-Khalifa, S.E.; Wuest, W.M.*; Minbiole, K.P.C.*

 

Bioorg. Med. Chem. Lett. 2017 27, 2107. DOI: 10.1016/j.bmcl.2017.03.077

32The Development of Next Generation Pyridinium-Based multiQAC Antiseptics

Al-Khalifa, S.E.; Jennings, M.C.; Wuest, W.M.*; Minbiole, K.P.C.*

ChemMedChem 2017 12, 280 DOI:10.1002/cmdc.201600546

31Polymeric Quaternary Ammonium Compounds: Versatile Antimicrobial Materials

Zubris, D.L.*; Minbiole, K.P.C.*; Wuest, W.M.*

Current Topics in Medicinal Chemistry 2017 17, 305 DOI: 10.2174/1568026616666160829155805

30Building a Better QAC: Branched Tetracationic Antiseptics

Forman, M.E.; Jennings, M.C.; Wuest, W.M.*; Minbiole, K.P.C.*

ChemMedChem 2016 11, 1401  DOI: 10.1002/cmdc.201600176

28From Antimicrobial Activity to Mechanism of Resistance: The Multifaceted Role of Simple Quaternary Ammonium Compounds in Bacterial Eradication

Minbiole, K.P.C.*; Jennings, M.C.; Ator, L.E.; Black, J.W.; Grenier, M.C.; LaDow, J.E.; Caran, K.L.; Seifert, K.; Wuest, W.M.*

Tetrahedron 2016 72, 3559. DOI: 10.1016/j.tet.2016.01.014

26Structure-Resistance Relationships: Interrogating Antiseptic Resistance in Bacteria with Multicationic Quaternary Ammonium Dyes

Forman, M.E.; Fletcher, M.H.; Jennings, M.C.; Duggan, S.M.; Minbiole, K.P.C.*; Wuest, W.M.

 

ChemMedChem 2016 11, 958.DOI: 10.1002/cmdc.201600095

25The Enantioselective Synthesis and Biological Evaluation of Chimeric Promysalin Analogs Facilitated by Diverted Total Synthesis

Knouse, K.W.; Wuest, W.M

 

J. Antibiotics 2016 69, 337. DOI: 10.1038/ja.2016.4 (invited paper for Amos B. Smith, III issue)

24Natural Product-Derived Quaternary Ammonium Compounds with Potent Antimicrobial Activity

Joyce, M.D.; Jennings, M.C.; Santiago, C.N.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.*

.Antibiotics 2016 69, 344. DOI: 10.1038/ja.2015.107 (invited paper for A.B. Smith, III issue)

22The rhizosphere microbiome: A playground for natural product chemists

Keohane, C.E.; Steele, A.D.; Wuest, W.M.*

Synlett 2015 26, 2739. DOI: 10.1055/s-0035-1560711 (invited Synpact Paper)

21Scaffold-hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials

 Mitchell, M.A.; Iannetta, A.A.; Jennings, M.C.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.*

ChemBioChem 2015 16, 2299. DOI: 10.1002/cbic.201500381  

20Total Synthesis and Biological Evaluation of (-)-Promysalin

Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.*

J. Am. Chem. Soc. 2015 137, 7314. DOI: 10.1021/jacs.5b04767

17Molecular Simulation of Conformational Pre-organization in Cyclic RGD Peptides

Wakefield, A.E.; Wuest, W.M.; Voelz, V.A.

J. Chem. Inf. Model, 2015 55, 806. DOI: 10.1021/ci500768u

14Beyond paraquats: Dialkyl 3,3′- and 3,4′-bipyridinium amphiphiles as antibacterial agents

Ator, L.C.; Jennings, M.C.; McGettigan, A.R.; Paul, J.J.; Wuest, W.M.*; Minbiole, K.P.C.

Bioorg. Med. Chem. Lett.  2014  24, 3706.  DOI: 10.1016/j.bmcl.2014.07.024 

8TMEDA-derived biscationic amphiphiles: An economical preparation of potent antibacterial agents

Black, J.W.; Jennings, M.C.; Azarewicz, J.; Paniak, T.J.; Grenier, M.C.; Wuest, W.M.*; Minbiole, K.P.C.*

Bioorg. Med. Chem Lett. 2014 24, 99.