Publications
(undergraduate authors, co-first authors# )
153Combatting Resistance: Natural Products as Tools to Drive the Discovery of Untapped Antibiotic Targets
Hedges, M.; Di Carlo, C.M.; Wuest, W.*
Chem. Commun. 2025, 61, 14039
(Invited Review)
145From Natural Products to Small Molecules: Recent Advancements in Anti-MRSA Therapeutics
Smith, J.R.; LeBlanc, A.R.; Wuest, W.M.*
ACS Med. Chem. Lett. 2025, 16 (4), 542-551
139Recent Developments in Antimicrobial Small Molecule Quaternary Phosphonium Compounds (QPCs) – Synthesis and Biological Insights
McDonough, D.; Sanchez, C.A.; Wuest, W.M.*; Minbiole, K.P.C.*
RSC Med. Chem. 2025, 16, 1000-1022
137Metal Chelation as an Antibacterial Strategy for Pseudomonas aeruginosa and Acinetobacter baumannii
Golden, M.M.; Heppe, A.C.; Zaremba, C.L.*; Wuest, W.M.*
RSC Chem. Biol. 2024, 5, 1083-1096
133Siderophores: A Case Study in Translational Chemical Biology
LeBlanc, A.R.; Wuest, W.M.*
Biochemistry 2024, 63 (15), 1877-1891
116Beyond Ergosterol: Strategies for Combatting Antifungal Resistance in Aspergillus fumigatus and Candida auris
Cruz, R.; Wuest, W.M.*
Tetrahedron 2023, 133, 133268
(Tetrahedron Special Issue Honoring Professor John Wood)
115Ribosome-Targeting Antibiotics and Resistance via Ribosomal RNA Methylation
Jeremia, L.; Deprez, B.E.; Dey, D.; Conn, G.L.*; Wuest, W.M.*
RSC Med. Chem. 2023, 14, 624-643
(Invited Review for Special Issue on Antibiotic Resistance)
101Collaboration in natural product total synthesis: Carolacton – a decade of discovery
Solinski, A.E.; Wuest, W.M.*
Synlett 2021, 32 (03), 241-248
97Using Membrane Perturbing Small Molecules to Target Chronic Persistent Infections
Schrank, C.L.; Wilt, I.K.; Monteagudo Ortiz, C.; Haney, B.A.; Wuest, W.M.*
RSC Med. Chem. 2021, 12, 1312-1324
(Invited Review)
96The Silent Pandemic: Emergent Antibiotic Resistances Following the Global Response to SARS-CoV-2
Mahoney, A.R.#; Safaee, M.M.#; Wuest, W.M.; Furst, A.L.*
iScience 2021, 24 (4), 102304
94Mining for Mouth Metabolites
Scharnow, A.M.; Wuest, W.M.*
Nat. Chem. Biol. 2021, 17, 505-506
(Invited Highlight)
86A Look Around the West Indies: The Spices of Life are Secondary Metabolites
Demeritte, A.; Wuest, W.M.*
Bioorg. Med. Chem. 2020, 28 (23), 115792
(Invited Review)
85Building trans-Bicyclo[4.4.0]decanes/decenes in Complex Multifunctional Frameworks: The Case for Antibiotic Development
Zhang, W.#; Kaplan, A.R.#; Davison, E.K.; Freeman, J.L.; Brimble, M.A.; Wuest, W.M.*
Nat. Prod. Rep. 2021, 38, 880-889
84Advancements in the Development of Non-Nitrogen-Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance
Carden, R.G.; Sommers, K.J.; Schrank, C.L.; Leitgeb, A.J.; Feliciano, J.A.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2020, 15 (21), 1974-1984
80Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?
Schrank, C.L.; Minbiole, K.P.C.*; Wuest, W.M.*
ACS Infect. Dis. 2020, 6 (7), 1553-1557
(Over 40,000 views in a year)
74Virulence Attenuating Combination Therapy: A Potential Multi-Target Synergy Approach to Treat Pseudomonas aeruginosa Infections in Cystic Fibrosis Patients
Shaw, E.; Wuest, W.M.*
RSC Med. Chem. 2020, 11, 358-369
69More QACs, More Questions: Recent Advances in Structure Activity Relationships and Hurdles in Understanding Resistance Mechanisms
Morrison, K.R.; Allen, R.A.; Minbiole, K.P.C.*; Wuest, W.M.*
Tetrahedron Lett. 2019, 60 (37), 150935
(Invited Digest)
62Hijacking the Bacterial Circuitry of Biofilm Processes via Chemical “Hot-Wiring”: An Under-explored Avenue for Therapeutic Development
Wilt, I.K.; Hari, T.P.A.; Wuest, W.M.*
ACS Infect. Dis. 2019, 5 (6), 789-795
(Invited Viewpoint)
61Signed, Sealed, Delivered: Conjugate and Prodrug Strategies as Targeted Delivery Vectors for Antibiotics
Cheng, A.V.; Wuest, W.M.*
ACS Infect. Dis. 2019, 5 (6), 816-828
59Connecting Iron Acquisition and Biofilm Formation in the ESKAPE Pathogens as a Strategy for Combatting Antibiotic Resistance
Post, S.J.; Shapiro, J.A.; Wuest, W.M.*
MedChemComm 2019, 10, 505-512
(Invited Review for the Antibiotic Resistance Issue)
58Targeting S. mutans Biofilms: A Perspective on Preventing Dental Caries
Scharnow, A.M.; Solinski, A.E.; Wuest, W.M.*
MedChemComm 2019, 10, 1057-1067
(Invited Review for the New Talent Collection)
49From General to Specific: Can Pseudomonas Primary Metabolism Be Exploited for Narrow-Spectrum Antibiotics?
Shapiro, J.A.; Kaplan, A.R.; Wuest, W.M.*
ChemBioChem 2019, 20 (1), 34-39
(Invited Concept, Highlighted in the 20th Anniversary Issue)
42Polymeric Quaternary Ammonium Compounds: Versatile Antimicrobial Materials
Zubris, D.L.*; Minbiole, K.P.C.*; Wuest, W.M.*
Curr. Top. Med. Chem. 2017, 17 (3), 305-318
(Invited Review)
38Natural Products as Platforms to Overcome Antibiotic Resistance
Rossiter, S.E.; Fletcher, M.H.; Wuest, W.M.*
Chem. Rev. 2017, 117 (19), 12415-12474
28Twelve-Membered Macrolactones: Privileged Scaffolds for the Development of New Therapeutics
Brzozowski, R.S.; Wuest, W.M.*
Chem. Biol. Drug Des. 2017, 89 (2), 169-191
(Invited Review)
23The Rhizosphere Microbiome: A Playground for Natural Product Chemists
Keohane, C.E.; Steele, A.D.; Wuest, W.M.*
Synlett 2015, 26 (20), 2739-2744
18Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance
Jennings, M.C.; Minbiole, K.P.C.; Wuest, W.M.*
ACS Infect. Dis. 2015, 1 (7), 288-303
(Most cited publication in ACS Infectious Diseases)
15Draining the Moat: Disrupting Bacterial Biofilms with Natural Products
Fletcher, M.H.; Jennings, M.C.; Wuest, W.M.*
Tetrahedron 2014, 70 (37), 6373-6383
(Invited Review)