Publications
(undergraduate authors, co-first authors# )
150Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase
Dey, D.; Deprez, B.E.; Zelinskaya, N.; Castro, J.M.; Wuest, W.M.*; Conn, G.L.*
ACS Infect. Dis. 2025, 11 (8), 2276-2286
147Target-Guided Design and Synthesis of Aryl-Functionalized Promysalin Analogs
Golden, M.M.#; Brzezinski, C.U.#; Wuest, W.M.*
ChemBioChem 2025, 26 (10), e202401030
135Leveraging Natural Product-Inspired Antifungals to Investigate the Mechanism of Action of Peniciaculin A
Wilt, I.K.; Demeritte, A.R.; Kim, A.T.; Wang, W.; Wuest, W.M.*
ChemMedChem 2024, 19 (24), e202400500
127Investigating the Role of Metabolism for Antibiotic Combination Therapies in Pseudomonas aeruginosa
Golden, M.M.; Post, S.J.; Rivera, R.; Wuest, W.M.*
ACS Infect. Dis. 2023, 9 (12), 2386-2393
126Di-Berberine Conjugates as Chemical Probes of Pseudomonas aeruginosa MexXY-OprM Efflux Function and Inhibition
Kavanaugh. L.G.#; Mahoney, A.R.#; Dey, D.; Wuest, W.M.*; Conn, G.L.*
npj Antimicrob. Resist. 2023, 1, 12
120Structure-Based Design of Promysalin Analogues to Overcome Mechanisms of Bacterial Resistance
Mahoney, A.R.; Storek, K.M.; Wuest, W.M.*
ACS Omega 2023, 8 (13), 12558-12564
119Antimicrobial Activity of a New Class of Synthetic Retinoid Antibiotics and Comparator Agents Against Ocular Staphylococci
André, C.; Schrank, C.L.; Cheng Jaramillo, A.V.; Mylonakis, E.; Wuest, W.M.; Gilmore, M.S.; Kim, W.; Bispo, P.J.M.*
Front. Antibiot. 2023, 2, 1101450
118Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection
Huang, X.-w.#; Pan, W.#; Zhong, M.-z.; Chhonker, Y.S.; Steele, A.D.; Keohane, C.E.; Mishra, B.; Lucas, L.O.F.R.; Murry, D.J.; Ausubel, F.M.; Wuest, W.M.; Li, C.-x.*; Mylonakis, E.*
Antimicrob. Agents Chemother. 2023, 67 (4), e01679-22
106Exploration of Inhibitors of the Bacterial LexA Repressor-Protease
Cheng Jaramillo, A.V.#; Cory, M.B.#; Li, A.; Kohli, R.M.*; Wuest, W.M.*
Bioorg. Med. Chem. Lett. 2022, 65, 128702
105nTZDpa (Non-Thiazolidinedione PPARγ Partial Agonist) Derivatives Retain Antimicrobial Activity Without Improving Renal Toxicity
Dekarske, M.M.; Felix, L.O.; Monteagudo Ortiz, C.; Csatary, E.E.; Mylonakis, E.; Wuest, W.M.*
Bioorg. Med. Chem. Lett. 2022, 64, 128678
90Tricepyridinium-Inspired QACs Yield Potent Antimicrobials and Provide Insight into QAC Resistance
Garrison, M.A.#; Mahoney, A.R.#; Wuest, W.M.*
ChemMedChem 2020, 16 (3), 463-466
87Synthesis and Biological Evaluation of an Antibacterial Azaborine Retinoid Isostere
Haney, B.A.; Schrank, C.L.; Wuest, W.M.*
Tetrahedron Lett. 2021, 62, 152667
(Invited Issue in Honor of Dale Boger)
78Addition of Ethylamines to the Phenols of Bithionol and Synthetic Retinoids Does Not Elicit Activity in Gram-Negative Bacteria
Cheng, A.V.#; Schrank, C.L.#; Escobar, I.E.; Mylonakis, E.; Wuest, W.M.*
Bioorg. Med. Chem. Lett. 2020, 30 (9), 127099
77Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase
Post, S.J.#; Keohane, C.E.#; Rossiter, L.M.; Kaplan, A.R.; Khowsathit, J.; Matuska, K.; Karanicolas, J.; Wuest, W.M.*
ACS Infect. Dis. 2020, 6 (6), 1372-1377
(Antibiotics Special Issue)
75Broadening Activity of Polymyxin by Quaternary Ammonium Grafting
Ongwae, G.M.; Morrison, K.R.; Allen, R.A.; Kim, S.; Im, W.; Wuest, W.M.; Pires, M.M.*
ACS Infect. Dis. 2020, 6 (6), 1427-1435
(Antibiotics Special Issue)
70A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism
Ochoa, C.#; Solinski, A.E.#; Nowlan, M.; Dekarske, M.M.; Wuest, W.M.*; Kozlowski, M.C.*
ACS Infect. Dis. 2020, 6 (1), 74-79
67A Selective Membrane-Targeting Repurposed Antibiotic with Activity Against Persistent Methicillin-Resistant Staphylococcus aureus
Kim, W.; Zou, G.; Hari, T.P.A.; Wilt, I.K.; Zhu, W.; Galle, N.; Faizi, H.A.; Hendricks, G.L.; Tori. K.; Pan, W.; Huang, X.; Steele, A.D.; Csatary, E.E.; Dekarske, M.M.; Rosen, J.L.; de Queiroz Ribeiro, N.; Lee, K.; Port, J.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gao, H.; Ausubel, F.M.*; Mylonakis,E.*
Proc. Natl. Acad. Sci. U.S.A. 2019, 116 (33), 16529-16534
66Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids
Cheng, A.V.; Kim, W.; Escobar, I.E.; Mylonakis, E.; Wuest, W.M.*
ACS Med. Chem. Lett. 2020, 11 (3), 393-397
(Featured in the Women in Medicinal Chemistry Issue)
65Combined Inhibition of Aurora A and p21-Activated Kinase 1 as a New Treatment Strategy in Breast Cancer
Korobeynikov, V.; Borakove, M.; Feng, Y.; Wuest, W.M.; Koval, A.B.; Nikonova, A.S.; Serebriiskii, I.; Chernoff, J.; Borges, V.F.; Golemis, E.A.; Shagisultanova, E.*
Breast Cancer Research and Treatment 2019, 117, 369-382