Publications
Most Impactful Publications
(undergraduate authors, co-first authors# )
136Bisphosphonium Amphiphiles Yield Insights into Gram-Negative Bacterial Disinfectant Resistance and Cell Membrane Interactions
133Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship Between Self-assembly and Cytolytic Activity
Laguera, B., Golden, M.M., Wang, F., Gnewou, O., Tuachi, A., Egelman, E.H., Wuest, W.M. and Conticello, V.P.
Angew. Chem. Int. Ed. 2025, e202500040.
123In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe
Amber M. Scharnow, Amy E. Solinski, Sebastian Rowe, Ines Drechsel, Hua Zhang, Elana Shaw, Julia E. Page, Hui Wu, Stephan A. Sieber, William M. Wuest*
J. Am. Chem. Soc. 2024, 146, 33, 23449–23456
110Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection
Huang, X.; Pan, W.; Zhong, M-Z.; Chhonker. Y.S.; Steele, A.D.; Keohane, C.E.; Mishra, B.; Lucas, O.F.R.; Murry. D.J.; Ausubel, F.M.; Wuest. W.M.; Li, C-X.; Mylonakis. E.*
Antimicrobial Agents and Chemotherapy 2023 67, e10679-22 DOI: 10.1128/aac.01679-22
95Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles to Evade Disinfectant Resistance
Sommers, K.J.#; Michaud, M.E.#; Hogue, C.E.; Scharnow, A.M.; Amoo, L.E.; Peterson, A.A.; Carden, R.G.; Minbiole, K.P.C.*; Wuest. W.M.*
ACS Infectious Diseases 2022 8, 387. DOI: 10.1021/acsinfecdis.1c00611
85Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumannii via Dysregulation of Heme Biosynthesis
Hubner, I.; Shapiro, J.A.; Hobmann, J.; Drechsel, J.; Hacker, S.M.; Rather, P.N.; Piepar, D.H.; Wuest, W.M.; Sieber, S.A.
ACS Central Science 2021 7, 488 DOI: 10.1021/acscentralsci.0c01621
67Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study
Al-Khalifa, S.; Jennings, M.C.; Granata, D.; Klein, M.; Wuest, W.M.*; Minbiole, K.P.C.*; Carnevale, V.*
ChemBioChem 2020 21, 1510 DOI: 10.1002/cbic.201900698
65Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms
Le, P.; Kunold, E.; Macsics, R.; Rox, K.; Jennings, M.C.; Ugur, I.; Reinecke, M.; Chaves-Moreno, D.; Hackl, M.W.; Fetzer, C.; Mandl, F.A.M.; Lehmann, J.; Korotkov, V.S.; Hacker, S.M.; Kuster, B.; Antes, I.; Pieper, D.H.; Rohde, M.; Wuest, W.M.; Medina, E.; Sieber, S.A.*
Nature Chemistry 2020 12, 145 DOI: s41557-019-0378-7
63A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus
Kim, W.; Zou, G.; Hari, T.P.A.; Wilt, I.K.; Zhu, W.; Galle, N.; Faizi, H.A.; Hendricks, G.L.; Tori. K.; Pan, W.; Huang, X.; Steele, A.D.; Csatary, E.E.; Dekarske, M.M.; Rosen, J.L.; de Queiroz Ribiero, N.; Lee, K.; Port, J.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gao, H.; Ausubel, F.M.; Mylonakis,E.
Proc. Nat. Acad. Sci. 2019 116, 16529 DOI: 10.1073/pnas.1904700116 (Featured on NPR)
60Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans
Solinski, A.E.; Scharnow, A.M.; Fraboni, A.J., Wuest, W.M.*
ACS Infectious Diseases 2019 5, 1480 DOI:10.1021/acsinfecdis.9b00213
59The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa
Zhao, W.; Cross, A.R.; Crowe-McAuliffe, C.; Weigert-Munoz, A.; Csatary, E.E.; Solinski, A.E.; Krysiak, J.; Goldberg, J.B.; Wilson, D.N.; Medina, E.; Wuest, W.M.; Sieber S.A.*
Angew. Chem. Int. Ed. 2019 58, 8581 DOI: 10.1002/anie.201903472
54An Investigation into Rigidity-Activity Relationships in bisQAC Amphiphilic Antiseptics
Kontos, R.C.; Schallenhammer, S.A.; Bentley, B.S.; Morrison, K.R.; Feliciano, J.A.; Tasca, J.A.; Kaplan, A.R.; Bezpalko, M.W.; Kassel, S.W.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2019 14, 83 DOI: 10.1002/cmdc.201800622
53Identification of Specific and Non-specific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK)
Shapiro, J.A.; Varga, J.J.; Parsonage, D.; Walton, W.; Redinbo, M.R.; Ross, L.J.; White, E.L.; Bostwick, R.*; Wuest, W.M.*; Clairborne, A.*; Goldberg, J.B.*
ChemMedChem 2019 14, 78 DOI: 10.1002/cmdc.201800652
51Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space
Kearney, S.E.; Zahoransky-Kohalmi, G.; et al.
ACS Central Science 2018 4, 1727 DOI: 10.1021/acscentsci.8b00747
50Epoxy isonitriles, a unique class of antibiotics – Synthesis of their metabolites and biological investigations
Ernouf, G.; Wilt, I.K.; Zahim, S.; Wuest, W.M.*
ChemBioChem 2018 19, 2448 (Selected for ChemBio Talents Issue) DOI: 10.1002/cbic
48Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters
Kim, W.; Steele, A.D.; Zhu, W.; Csatary, E.E.; Fricke, N.; Dekarske, M.M.; Jayamani, E.; Pan, W.; Kwon, B.; Sinitsa, I.F.; Rosen, J.; Conery, A.L.; Fuchs, B.B.; Vlahovska, P.M.; Ausubel, F.M.; Gao, H.; Wuest, W.M.*; Mylonakis, E.
ACS Infectious Diseases 2018 4, 1540 DOI: 10.1021/acsinfecdis.8b00161
47Transcriptomic profiling suggest that Promysalin alters metabolic flux, motility, and iron regulation in Pseudomonas putida KT2440
Giglio, K.; Keohane, C.E.; Stodghill, P.; Steele, A.D.; Fetzer, C.; Sieber, S.A.; Filiatrault, M.J.*; Wuest, W.M.*
ACS Infectious Diseases 2018 4, 1179. DOI: 10.1021/acsinfecdis.8b00041
46A new class of synthetic retinoid antibiotics effective against bacterial persisters
Kim, W.; Zhu, W.; Hendricks, G.L.; Van Tyne, D.; Steele, A.D.; Keohane, C.E.; Fricke, N.; Conery, A.L.; Shen, S.; Pan, W.; Lee, K.; Rajamuthiah, R.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gilmore, M.S.; Gao, H.; Ausubel, F.M.; Mylonakis, E.
Nature 2018 556, 103. DOI: 10.1038/nature26157
45Claramines: A new class of broad-spectrum antimicrobial agents with bimodal activity
Blanchet, M.; Borselli, D.; Rodallec, A.; Peiretti, F.; Vidal, N.; Bolla, J.M.; Digiorgio, C.; Morrison, K.R.; Wuest, W.M.; Brunel, J.M*
ChemMedChem 2018 13, 1018 DOI: 10.1002/cmdc.201800073
44A dual inhibitor of Staphylococcus aureus virulence and biofilm attenuates expression of major toxins and adhesins
Hofbauer, B.; Vomacka, J.; Stahl, M.; Korotkov, V.; Jennings, M.C.; Wuest, W.M.; Sieber, S.A.*
Biochemistry 2018 57, 1814. DOI: 10.1021/acs.biochem.7b01271