Publications

(undergraduate authors, co-first authors# )

149Repurposing a Drug to Punish Carbapenem-Resistant Acinetobacter baumannii

Colquhoun, J.M.; Brzezinski, C.U.; Ji, A.; Marotta, J.; Elsen, F.A.V.; Bonomo, R.A.; May, K.L.; Sieber, S.A.; Grabowicz, M.; Wuest, W.M.; Rather, P.N.*

Proc. Natl. Acad. Sci. U.S.A 2025, 122 (24), e2423650122

144Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship Between Self-assembly and Cytolytic Activity

Laguera, B.#; Golden, M.M.#; Wang, F.#; Gnewou, O.; Tuachi, A.; Egelman, E.H.*; Wuest, W.M.*; Conticello, V.P.*

Angew. Chem. Int. Ed. 2025, 64 (21), e202500040

134In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe

Scharnow, A.M.#; Solinski, A.E.#; Rowe, S.; Drechsel, I.; Zhang, H.; Shaw, E.; Page, J.E.; Wu, H.; Sieber, S.A.; Wuest, W.M.*

J. Am. Chem. Soc. 2024, 146 (33), 23449–23456

89Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumannii via Dysregulation of Heme Biosynthesis

Hübner, I.; Shapiro, J.A.; Hoßmann, J.; Drechsel, J.; Hacker, S.M.; Rather, P.N.; Pieper, D.H.; Wuest, W.M.; Sieber, S.A.*

ACS Cent. Sci. 2021, 7 (3), 488-498

71Repurposing Human Kinase Inhibitors to Create an Antibiotic Active Against Drug-Resistant Staphylococcus aureus, Persisters and Biofilms

Le, P.; Kunold, E.; Macsics, R.; Rox, K.; Jennings, M.C.; Ugur, I.; Reinecke, M.; Chaves-Moreno, D.; Hackl, M.W.; Fetzer, C.; Mandl, F.A.M.; Lehmann, J.; Korotkov, V.S.; Hacker, S.M.; Kuster, B.; Antes, I.; Pieper, D.H.; Rohde, M.; Wuest, W.M.; Medina, E.; Sieber, S.A.*

Nat. Chem. 2020, 12, 145-158

64Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans

Solinski, A.E.; Scharnow, A.M.; Fraboni, A.J., Wuest, W.M.*

ACS Infect. Dis. 2019, 5 (8), 1480-1486

60The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa

Zhao, W.; Cross, A.R.; Crowe-McAuliffe, C.; Weigert-Munoz, A.; Csatary, E.E.; Solinski, A.E.; Krysiak, J.; Goldberg, J.B.; Wilson, D.N.; Medina, E.; Wuest, W.M.; Sieber S.A.*

Angew. Chem. Int. Ed. 2019, 58 (25), 8581-8584

54Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK)

Shapiro, J.A.; Varga, J.J.; Parsonage, D.; Walton, W.; Redinbo, M.R.; Ross, L.J.; White, E.L.; Bostwick, R.*; Wuest, W.M.*; Claiborne, A.*; Goldberg, J.B.*

ChemMedChem 2019, 14 (1), 78-82

48Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas putida KT2440

Giglio, K.M.#; Keohane, C.E.#; Stodghill, P.V.; Steele, A.D.; Fetzer, C.; Sieber, S.A.; Filiatrault, M.J.*; Wuest, W.M.*

ACS Infect. Dis. 2018, 4 (8), 1179-1187

45Dual Inhibitor of Staphylococcus aureus Virulence and Biofilm Attenuates Expression of Major Toxins and Adhesins

Hofbauer, B.#; Vomacka, J.#; Stahl, M.; Korotkov, V.S.; Jennings, M.C.; Wuest, W.M.; Sieber, S.A.*

Biochemistry 2018, 57 (11), 1814-1820

43Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase

Keohane, C.E.; Steele, A.D.; Fetzer, C.; Khowsathit, J.; Van Tyne, D.; Moynié, L.; Gilmore, M.S.; Karanicolas, J.; Sieber, S.A.; Wuest, W.M.*

J. Am. Chem. Soc. 2018, 140 (5), 1774-1782

33Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms

Solinski, A.E.#; Koval, A.B.#; Brzozowski, R.S.#; Morrison, K.R.; Fraboni, A.J.; Carson, C.E.; Eshraghi, A.R.; Zhou, G.; Quivey, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest, W.M.*

J. Am. Chem. Soc. 2017, 139 (21), 7188-7191

27Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity

Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.*

J. Am. Chem. Soc. 2016, 138 (18), 5833-5836