Publications
(undergraduate authors, co-first authors# )
149Repurposing a Drug to Punish Carbapenem-Resistant Acinetobacter baumannii
Colquhoun, J.M.; Brzezinski, C.U.; Ji, A.; Marotta, J.; Elsen, F.A.V.; Bonomo, R.A.; May, K.L.; Sieber, S.A.; Grabowicz, M.; Wuest, W.M.; Rather, P.N.*
Proc. Natl. Acad. Sci. U.S.A 2025, 122 (24), e2423650122
138Highly Effective Biocides against Pseudomonas aeruginosa Reveal New Mechanistic Insights Across Gram-Negative Bacteria
Sanchez, C.A.#; Vargas-Cuebas, G.G.#; Michaud, M.E.; Allen, R.A.; Morrison-Lewis, K.R.; Siddiqui, S.; Minbiole, K.P.C.*; Wuest, W.M.*
ACS Infect. Dis. 2024, 10 (11), 3868–3879
134In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe
Scharnow, A.M.#; Solinski, A.E.#; Rowe, S.; Drechsel, I.; Zhang, H.; Shaw, E.; Page, J.E.; Wu, H.; Sieber, S.A.; Wuest, W.M.*
J. Am. Chem. Soc. 2024, 146 (33), 23449–23456
133Siderophores: A Case Study in Translational Chemical Biology
LeBlanc, A.R.; Wuest, W.M.*
Biochemistry 2024, 63 (15), 1877-1891
128Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold
Shapiro, J.S.; Post, S.J.; Smith, G.C.; Wuest, W.M.*
Org. Lett. 2023, 25 (51), 9243–9248
117Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents
Brayton, S.R.; Toles, Z.E.A.; Sanchez, C.A.; Michaud, M.E.; Thierer, L.M.; Keller, T.M.; Risener, C.J.; Quave, C.L.; Wuest, W.M.*; Minbiole, K.P.C.*
ACS Infect. Dis. 2023, 9 (4), 943-951
113Atom Economical QPCs: Phenyl-Free Biscationic Quaternary Phosphonium Compounds as Potent Disinfectants
Thierer, L.M.; Peterson, A.A.; Michaud, M.E.; Sanchez, C.A.; Brayton, S.R.; Wuest, W.M.*; Minbiole, K.P.C.*
ACS Infect. Dis. 2023, 9 (3), 609-616
107Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant Acinetobacter baumannii Clinical Isolates
Michaud, M.E.; Allen, R.A.; Morrison-Lewis, K.R.; Sanchez, C.A.; Minbiole, K.P.C.*; Post, S.J.*; Wuest, W.M.*
ACS Infect. Dis. 2022, 8 (11), 2307-2314
102Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance
Sommers, K.J.#; Michaud, M.E.#; Hogue, C.E.; Scharnow, A.M.; Amoo, L.E.; Peterson, A.A.; Carden, R.G.; Minbiole, K.P.C.*; Wuest, W.M.*
ACS Infect. Dis. 2022, 8 (2), 387-397
(Highlighted in Chemical and Engineering News)
96The Silent Pandemic: Emergent Antibiotic Resistances Following the Global Response to SARS-CoV-2
Mahoney, A.R.#; Safaee, M.M.#; Wuest, W.M.; Furst, A.L.*
iScience 2021, 24 (4), 102304
88Antibacterials
Cheng Jaramillo, A.V.; Wuest, W.M.
American Chemical Society, 2021
(Invited contributor for ACS In-Focus Series of E-books)
80Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?
Schrank, C.L.; Minbiole, K.P.C.*; Wuest, W.M.*
ACS Infect. Dis. 2020, 6 (7), 1553-1557
(Over 40,000 views in a year)
72Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study
Alkhalifa, S.; Jennings, M.C.; Granata, D.; Klein, M.; Wuest, W.M.*; Minbiole, K.P.C.*; Carnevale, V.*
ChemBioChem 2019, 21 (10), 1510-1516
71Repurposing Human Kinase Inhibitors to Create an Antibiotic Active Against Drug-Resistant Staphylococcus aureus, Persisters and Biofilms
Le, P.; Kunold, E.; Macsics, R.; Rox, K.; Jennings, M.C.; Ugur, I.; Reinecke, M.; Chaves-Moreno, D.; Hackl, M.W.; Fetzer, C.; Mandl, F.A.M.; Lehmann, J.; Korotkov, V.S.; Hacker, S.M.; Kuster, B.; Antes, I.; Pieper, D.H.; Rohde, M.; Wuest, W.M.; Medina, E.; Sieber, S.A.*
Nat. Chem. 2020, 12, 145-158
67A Selective Membrane-Targeting Repurposed Antibiotic with Activity Against Persistent Methicillin-Resistant Staphylococcus aureus
Kim, W.; Zou, G.; Hari, T.P.A.; Wilt, I.K.; Zhu, W.; Galle, N.; Faizi, H.A.; Hendricks, G.L.; Tori. K.; Pan, W.; Huang, X.; Steele, A.D.; Csatary, E.E.; Dekarske, M.M.; Rosen, J.L.; de Queiroz Ribeiro, N.; Lee, K.; Port, J.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gao, H.; Ausubel, F.M.*; Mylonakis,E.*
Proc. Natl. Acad. Sci. U.S.A. 2019, 116 (33), 16529-16534
64Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans
Solinski, A.E.; Scharnow, A.M.; Fraboni, A.J., Wuest, W.M.*
ACS Infect. Dis. 2019, 5 (8), 1480-1486
60The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa
Zhao, W.; Cross, A.R.; Crowe-McAuliffe, C.; Weigert-Munoz, A.; Csatary, E.E.; Solinski, A.E.; Krysiak, J.; Goldberg, J.B.; Wilson, D.N.; Medina, E.; Wuest, W.M.; Sieber S.A.*
Angew. Chem. Int. Ed. 2019, 58 (25), 8581-8584
50Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters
Kim, W.; Steele, A.D.; Zhu, W.; Csatary, E.E.; Fricke, N.; Dekarske, M.M.; Jayamani, E.; Pan, W.; Kwon, B.; Sinitsa, I.F.; Rosen, J.L.; Conery, A.L.; Fuchs, B.B.; Vlahovska, P.M.; Ausubel, F.M.; Gao, H.; Wuest, W.M.*; Mylonakis, E.*
ACS Infect. Dis. 2018, 4 (11), 1540-1545
47A New Class of Synthetic Retinoid Antibiotics Effective Against Bacterial Persisters
Kim, W.; Zhu, W.; Hendricks, G.L.; Van Tyne, D.; Steele, A.D.; Keohane, C.E.; Fricke, N.; Conery, A.L.; Shen, S.; Pan, W.; Lee, K.; Rajamuthiah, R.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gilmore, M.S.; Gao, H.; Ausubel, F.M.; Mylonakis, E.*
Nature 2018, 556, 103-107
44Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action
Steele, A.D.; Ernouf, G.; Lee, Y.-E.; Wuest, W.M.*
Org. Lett. 2018, 20 (4), 1126-1129
43Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase
Keohane, C.E.; Steele, A.D.; Fetzer, C.; Khowsathit, J.; Van Tyne, D.; Moynié, L.; Gilmore, M.S.; Karanicolas, J.; Sieber, S.A.; Wuest, W.M.*
J. Am. Chem. Soc. 2018, 140 (5), 1774-1782
38Natural Products as Platforms to Overcome Antibiotic Resistance
Rossiter, S.E.; Fletcher, M.H.; Wuest, W.M.*
Chem. Rev. 2017, 117 (19), 12415-12474
33Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms
Solinski, A.E.#; Koval, A.B.#; Brzozowski, R.S.#; Morrison, K.R.; Fraboni, A.J.; Carson, C.E.; Eshraghi, A.R.; Zhou, G.; Quivey, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest, W.M.*
J. Am. Chem. Soc. 2017, 139 (21), 7188-7191
27Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity
Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.*
J. Am. Chem. Soc. 2016, 138 (18), 5833-5836
20Total Synthesis and Biological Investigation of (–)-Promysalin
Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.*
J. Am. Chem. Soc. 2015, 137 (23), 7314-7317
19Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus
Jennings, M.C.; Buttaro, B.A.; Minbiole, K.P.C.; Wuest, W.M.*
ACS Infect. Dis. 2015, 1 (7), 304-309
18Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance
Jennings, M.C.; Minbiole, K.P.C.; Wuest, W.M.*
ACS Infect. Dis. 2015, 1 (7), 288-303
(Most cited publication in ACS Infectious Diseases)
9A Concise Synthesis of Carolacton
Hallside, M.S.; Brzozowski, R.S.; Wuest, W.M.*; Phillips, A.J.*
Org. Lett. 2014, 16 (4), 1148-1151
(Top 10 Downloaded Publication in Organic Letters between January-June 2014)