Publications
(undergraduate authors, co-first authors# )
158Topology-Aware Generation and Activity-Based Filtering: A Computational-Experimental Framework for Data-Scarce Quaternary Ammonium Compound Discovery
Ghaemi, S.; Consylman, A.; Pan, B.; Wu, A.; Petersen, A.; Chang, G.; McDonough, D.; Forman, M.; Bezold, E.L.; Wuest, W.M.*; Shehu, A.*; Zhao, L.*; Minbiole, K.P.C.*
J. Chem. Inf. Model. 2026, ASAP Article
157Studies toward Pestalachloride B: Synthesis of the 6/7/6 Tricyclic Scaffold
Deprez, B.E.; LeBlanc, A.R.; Yang, Q.W.; Smith, A.P.; Wuest, W.M.*
Org. Lett. 2026, ASAP Article
156Triscationic Bolaamphiphilic QACs – Optimizing Antibacterial Therapeutic Indices
Asante, J.Y.D.; Bezold, E.L.; Wuest, W.M.*; Minbiole, K.P.C.*
Bioorg. Med. Chem. Lett. 2025, 130441
155Cheap, Fast, Safe, Sustainable, and Positively Irresistible: The Future of Cationic Amphiphilic Disinfectant Development
Hedges, M.R.; Minbiole, K.P.C.*; Selinsky, B.S.*; Wuest, W.M.*
J. Med. Chem. 2025
154The Versatile Synthesis and Biological Evaluation of All-Alkyl Biscationic Quaternary Phosphonium Compounds: Atom-Economical and Potent Disinfectants
McDonough, D.; Bezold, E.L.; Wuest, W.M.*; Minbiole, K.P.C.*
RSC Med. Chem. 2025, Advance Article
153Combatting Resistance: Natural Products as Tools to Drive the Discovery of Untapped Antibiotic Targets
Hedges, M.; Di Carlo, C.M.; Wuest, W.*
Chem. Commun. 2025, 61, 14039
(Invited Review)
152An Instructible Chemist-AI Alignment Framework for Generating Quaternary Ammonium Compound Structures
Pan, B.; Ghaemi, S.; Consylman, A.J.; Zihao, Z.; Petersen, A.; Wu, A.; Chang, G.; McDonough, D.; Forman, M.A.; Bezold, E.L.; Wuest, W.M.; Minbiole, K.; Zhao, L.; Shehu, A.
Proceedings of the 31st ACM SIGKDD Conference on Knowledge Discovery and Data Mining V.2 (KDD ’25) 2025, 4740-4750
151Vancomycin Sensitization in Pseudomonas aeruginosa is Contingent on Limited Metabolic Flux
Golden, M.M.; Siddiqui, S.; Ohanaja, V.; Post, S.J.; Wuest, W.M.*
ACS Infect. Dis. 2025, 11 (8), 2169-2177
150Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase
Dey, D.; Deprez, B.E.; Zelinskaya, N.; Castro, J.M.; Wuest, W.M.*; Conn, G.L.*
ACS Infect. Dis. 2025, 11 (8), 2276-2286
149Repurposing a Drug to Punish Carbapenem-Resistant Acinetobacter baumannii
Colquhoun, J.M.; Brzezinski, C.U.; Ji, A.; Marotta, J.; Elsen, F.A.V.; Bonomo, R.A.; May, K.L.; Sieber, S.A.; Grabowicz, M.; Wuest, W.M.; Rather, P.N.*
Proc. Natl. Acad. Sci. U.S.A 2025, 122 (24), e2423650122
148Bisphosphonium Amphiphiles Yield Insights into Gram-Negative Bacterial Disinfectant Resistance and Cell Membrane Interactions
Bezold, E.L.#; Young, A.L.E.#; Jaworski, C.J.; Minbiole, K.P.C.; Sanchez, C.A.*; Wuest, W.M.*
ACS Omega 2025, 10 (23), 25076-25083
147Target-Guided Design and Synthesis of Aryl-Functionalized Promysalin Analogs
Golden, M.M.#; Brzezinski, C.U.#; Wuest, W.M.*
ChemBioChem 2025, 26 (10), e202401030
146Not All Disinfectants are Created Equal: The Importance of Mechanistic Understanding to Drive Research Forward
Bezold, E.L.; Minbiole, K.P.C.*; Wuest, W.M.*
Future Microbiology 2025, 20 (6), 445-447
145From Natural Products to Small Molecules: Recent Advancements in Anti-MRSA Therapeutics
Smith, J.R.; LeBlanc, A.R.; Wuest, W.M.*
ACS Med. Chem. Lett. 2025, 16 (4), 542-551
144Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship Between Self-assembly and Cytolytic Activity
Laguera, B.#; Golden, M.M.#; Wang, F.#; Gnewou, O.; Tuachi, A.; Egelman, E.H.*; Wuest, W.M.*; Conticello, V.P.*
Angew. Chem. Int. Ed. 2025, 64 (21), e202500040
142Microbial Changes Occurring During Oronasal Fistula Wound Healing
Goudy, S.L.*; Bradley, H.L.; Gacasan, C.A.; Toma, A.; Sekar, K.P.C.; Wuest, W.M.*; Tomov, M.; Serpooshan, V.; Coskun, A.; Jones, R.M.
Microorganisms 2025, 13 (2), 327
141Resorcinol-based Bolaamphiphilic Quaternary Ammonium Compounds
Asante, J.Y.D.; Casey, C.M.; Bezold, E.L.; Fernando, A.; McDonough, D.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2025, 20 (8), e202400932
139Recent Developments in Antimicrobial Small Molecule Quaternary Phosphonium Compounds (QPCs) – Synthesis and Biological Insights
McDonough, D.; Sanchez, C.A.; Wuest, W.M.*; Minbiole, K.P.C.*
RSC Med. Chem. 2025, 16, 1000-1022
138Highly Effective Biocides against Pseudomonas aeruginosa Reveal New Mechanistic Insights Across Gram-Negative Bacteria
Sanchez, C.A.#; Vargas-Cuebas, G.G.#; Michaud, M.E.; Allen, R.A.; Morrison-Lewis, K.R.; Siddiqui, S.; Minbiole, K.P.C.*; Wuest, W.M.*
ACS Infect. Dis. 2024, 10 (11), 3868–3879
137Metal Chelation as an Antibacterial Strategy for Pseudomonas aeruginosa and Acinetobacter baumannii
Golden, M.M.; Heppe, A.C.; Zaremba, C.L.*; Wuest, W.M.*
RSC Chem. Biol. 2024, 5, 1083-1096
136Adaptations to Cationic Biocide Exposure Differentially Influence Virulence Factors and Pathogenicity in Pseudomonas aeruginosa
Vargas-Cuebas, G.G.#; Sanchez, C.A.#; Bezold, E.L.; Walker, G.M.; Siddiqui, S.; Minbiole, K.P.C.; Wuest, W.M.*
Virulence 2024, 15 (1), 2397503
135Leveraging Natural Product-Inspired Antifungals to Investigate the Mechanism of Action of Peniciaculin A
Wilt, I.K.; Demeritte, A.R.; Kim, A.T.; Wang, W.; Wuest, W.M.*
ChemMedChem 2024, 19 (24), e202400500
134In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe
Scharnow, A.M.#; Solinski, A.E.#; Rowe, S.; Drechsel, I.; Zhang, H.; Shaw, E.; Page, J.E.; Wu, H.; Sieber, S.A.; Wuest, W.M.*
J. Am. Chem. Soc. 2024, 146 (33), 23449–23456
133Siderophores: A Case Study in Translational Chemical Biology
LeBlanc, A.R.; Wuest, W.M.*
Biochemistry 2024, 63 (15), 1877-1891
132Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation
Brzezinski, C.U.#; LeBlanc, A.R.#; Clerici, M.G.; Wuest, W.M.*
Org. Lett. 2024, 26 (26), 5534-5538
131Bushy-Tailed QACs: The Development of Multicationic Quaternary Ammonium Compounds with a High Degree of Alkyl Chain Substitution
Toles, Z.E.A.; Thierer, L.M.; Wu, A.; Bezold, E.L.; Rachii, D.; Sanchez, C.A.; Vargas-Cuebas, G.G.; Keller, T.M.; Carroll, P.J.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2024, 19 (19), e202400301
130Exploring the Correlation of Dynamic Surface Tension with Antimicrobial Activities of Quaternary Ammonium-Based Disinfectants
Vargas-Cuebas, G.G.; Sanchez, C.A.; Brayton, S.R.; Nikoloff, A.; Masters, R.; Minbiole, K.P.C.*; Wuest, W.M.*
ChemMedChem 2024, 19 (16), e202400262
129Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures
Leatherbury, M.S.; Thierer, L.M.; Sanchez, C.A.; Vargas-Cuebas, G.G.; Petersen, A.A.; Amoo, L.E.; Bezold, E.L.; Washington, K.C.; Mistrot, M.B.; Zdilla, M.J.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2024, 19 (11), e202300718
128Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold
Shapiro, J.S.; Post, S.J.; Smith, G.C.; Wuest, W.M.*
Org. Lett. 2023, 25 (51), 9243–9248
127Investigating the Role of Metabolism for Antibiotic Combination Therapies in Pseudomonas aeruginosa
Golden, M.M.; Post, S.J.; Rivera, R.; Wuest, W.M.*
ACS Infect. Dis. 2023, 9 (12), 2386-2393
126Di-Berberine Conjugates as Chemical Probes of Pseudomonas aeruginosa MexXY-OprM Efflux Function and Inhibition
Kavanaugh. L.G.#; Mahoney, A.R.#; Dey, D.; Wuest, W.M.*; Conn, G.L.*
npj Antimicrob. Resist. 2023, 1, 12
125Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C
Allen, R.A.#; McCormack, C.E.M.#; Wuest, W.M.*
ChemMedChem 2023, 18 (22), e202300253
124Total Synthesis and Biological Investigation of Mindapyrroles A and B
Allen, R.A.; Wuest, W.M.*
ChemMedChem 2023, 18 (18), e202300235
(Highlighted as a Very Important Paper)
122Visible-Light/Nickel-Catalyzed Carboxylation of C(sp2) Bromides via Formate Activation
Smith, G.C.; Zhang, D.H.; Zhang, W.; Soliven, A.H.; Wuest, W.M.*
J. Org. Chem. 2023, 88 (13), 9565-9568
121A Versatile Strategy for the Synthesis of Various Lumazine Peptides
Zhang, W.#; Mahoney, A.R.#; Garrison, M.; Wuest, W.M.*
Med. Chem. Res. 2023, 32, 1481-1496
(Invited Issue in Honor of Dr. Nicholas Meanwell)
120Structure-Based Design of Promysalin Analogues to Overcome Mechanisms of Bacterial Resistance
Mahoney, A.R.; Storek, K.M.; Wuest, W.M.*
ACS Omega 2023, 8 (13), 12558-12564
119Antimicrobial Activity of a New Class of Synthetic Retinoid Antibiotics and Comparator Agents Against Ocular Staphylococci
André, C.; Schrank, C.L.; Cheng Jaramillo, A.V.; Mylonakis, E.; Wuest, W.M.; Gilmore, M.S.; Kim, W.; Bispo, P.J.M.*
Front. Antibiot. 2023, 2, 1101450
118Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection
Huang, X.-w.#; Pan, W.#; Zhong, M.-z.; Chhonker, Y.S.; Steele, A.D.; Keohane, C.E.; Mishra, B.; Lucas, L.O.F.R.; Murry, D.J.; Ausubel, F.M.; Wuest, W.M.; Li, C.-x.*; Mylonakis, E.*
Antimicrob. Agents Chemother. 2023, 67 (4), e01679-22
117Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents
Brayton, S.R.; Toles, Z.E.A.; Sanchez, C.A.; Michaud, M.E.; Thierer, L.M.; Keller, T.M.; Risener, C.J.; Quave, C.L.; Wuest, W.M.*; Minbiole, K.P.C.*
ACS Infect. Dis. 2023, 9 (4), 943-951
116Beyond Ergosterol: Strategies for Combatting Antifungal Resistance in Aspergillus fumigatus and Candida auris
Cruz, R.; Wuest, W.M.*
Tetrahedron 2023, 133, 133268
(Tetrahedron Special Issue Honoring Professor John Wood)
115Ribosome-Targeting Antibiotics and Resistance via Ribosomal RNA Methylation
Jeremia, L.; Deprez, B.E.; Dey, D.; Conn, G.L.*; Wuest, W.M.*
RSC Med. Chem. 2023, 14, 624-643
(Invited Review for Special Issue on Antibiotic Resistance)
114Double BAC and Triple BAC: A Systematic Analysis of the Disinfectant Properties of Multicationic Derivatives of Benzalkonium Chloride (BAC)
Toles, Z.E.A.; Wu, A.; Sanchez, C.A.; Michaud, M.E.; Thierer, L.M.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2023, 18 (10), e202300018
113Atom Economical QPCs: Phenyl-Free Biscationic Quaternary Phosphonium Compounds as Potent Disinfectants
Thierer, L.M.; Peterson, A.A.; Michaud, M.E.; Sanchez, C.A.; Brayton, S.R.; Wuest, W.M.*; Minbiole, K.P.C.*
ACS Infect. Dis. 2023, 9 (3), 609-616
112Generation and Characterization of Quaternary Ammonium Compounds via Deep Learning
Wang, Y.; Ghaemi, S.; Ding, A.; Du, Y.; Pan, B.; Qin, M.; Lin, X.; Petersen, A.A.; Leitgeb, A.; Alkhalifa, S.; Minbiole, K.; Wuest, W.; Zhao, L.*; Shehu, A.*
2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Las Vegas, NV, USA, 2022, pp. 3512-3519
111Property-Controllable Generation of Quaternary Ammonium Compounds
Pan, B.#; Wang, Y.#; Lin, X.#; Qin, M.#; Du, Y.; Ghaemi, S.; Ding, A.; Wang, S.; Alkhalifa, S.; Minbiole, K.; Wuest, W.M.; Petersen, A.; Leitgeb, A.; Shehu, A.*; Zhao, L.*
IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Workshops: Computational Structural Biology Workshop (CSBW), 2022-06-08
109Total Synthesis and Antibacterial Investigations of 1-Hydroxyboivinianin A
Wilt, I.K.; Demeritte, A.R.; Wang, W.; Wuest, W.M.*
ChemMedChem 2022, 17 (23), e202200363
(Highlighted as a Very Important Paper)
108Multi-objective Deep Data Generation with Correlated Property Control
Wang, S.; Guo, X.; Lin, X.; Pan, B.; Du, Y.; Wang, Y.; Ye, Y.; Petersen, A.A.; Leitgeb, A.; AlKhalifa, S.; Minbiole, K.; Wuest, W.; Shehu, A.; Zhao, L.*
Advances in Neural Information Processing Systems 2022
107Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant Acinetobacter baumannii Clinical Isolates
Michaud, M.E.; Allen, R.A.; Morrison-Lewis, K.R.; Sanchez, C.A.; Minbiole, K.P.C.*; Post, S.J.*; Wuest, W.M.*
ACS Infect. Dis. 2022, 8 (11), 2307-2314
106Exploration of Inhibitors of the Bacterial LexA Repressor-Protease
Cheng Jaramillo, A.V.#; Cory, M.B.#; Li, A.; Kohli, R.M.*; Wuest, W.M.*
Bioorg. Med. Chem. Lett. 2022, 65, 128702
105nTZDpa (Non-Thiazolidinedione PPARγ Partial Agonist) Derivatives Retain Antimicrobial Activity Without Improving Renal Toxicity
Dekarske, M.M.; Felix, L.O.; Monteagudo Ortiz, C.; Csatary, E.E.; Mylonakis, E.; Wuest, W.M.*
Bioorg. Med. Chem. Lett. 2022, 64, 128678
104Rigidity-Activity Relationships of bisQPC Scaffolds against Pathogenic Bacteria
Spahr, A.C.; Michaud, M.E.; Amoo, L.E.; Sanchez, C.A.; Hogue, C.E.; Thierer, L.M.; Gau, M.R.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2022, 17 (14), e202200224
102Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance
Sommers, K.J.#; Michaud, M.E.#; Hogue, C.E.; Scharnow, A.M.; Amoo, L.E.; Peterson, A.A.; Carden, R.G.; Minbiole, K.P.C.*; Wuest, W.M.*
ACS Infect. Dis. 2022, 8 (2), 387-397
(Highlighted in Chemical and Engineering News)
101Collaboration in natural product total synthesis: Carolacton – a decade of discovery
Solinski, A.E.; Wuest, W.M.*
Synlett 2021, 32 (03), 241-248
100Polycationic Amphiphiles as Antimicrobial Agents and Methods Using Same
Wuest, W.M.; Minbiole, K.P.C.
US2021/0403430A1, 2021
99Polycationic Amphiphiles as Antimicrobial Agents and Methods Using Same
Wuest, W.M.; Minbiole, K.P.C.
US11111216B2, 2021
98Promiscuous Pseudomonas: Uptake of Non-Endogenous Ligands for Iron Acquisition
Kaplan, A.R.; Wuest, W.M.*
Tetrahedron Lett. 2021, 75, 153204
(Invited Issue in Honor of Dale Boger)
97Using Membrane Perturbing Small Molecules to Target Chronic Persistent Infections
Schrank, C.L.; Wilt, I.K.; Monteagudo Ortiz, C.; Haney, B.A.; Wuest, W.M.*
RSC Med. Chem. 2021, 12, 1312-1324
(Invited Review)
96The Silent Pandemic: Emergent Antibiotic Resistances Following the Global Response to SARS-CoV-2
Mahoney, A.R.#; Safaee, M.M.#; Wuest, W.M.; Furst, A.L.*
iScience 2021, 24 (4), 102304
95Trivalent Sulfonium Compounds (TSCs): Tetrahydrothiophene-based Amphiphiles Exhibit Similar Antimicrobial Activity to Analogous Ammonium-based Amphiphiles
Feliciano, J.A.; Leitgeb, A.J.; Schrank, C.L.; Allen, R.A.; Minbiole, K.P.C.; Wuest, W.M.*; Carden, R.G.*
Bioorg. Med. Chem. Lett. 2021, 37, 127809
94Mining for Mouth Metabolites
Scharnow, A.M.; Wuest, W.M.*
Nat. Chem. Biol. 2021, 17, 505-506
(Invited Highlight)
93An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation
Kaplan, A.R.#; Schrank, C.L.#; Wuest, W.M.*
ChemMedChem 2021, 16 (16), 2487-2490
(Highlighted as a Very Important Paper; Selected for Cover Art)
92Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonads Demonstrating Siderophore-like Activity
Kaplan, A.R.; Musaev, D.G.; Wuest, W.M.*
ACS Infect. Dis. 2021, 7 (3), 544-551
91Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures
Sommers, K.J.; Bentley, B.S.; Carden, R.G.; Post, S.J.; Allen, R.A.; Kontos, R.C.; Black, J.W.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2020, 16 (3), 467-471
90Tricepyridinium-Inspired QACs Yield Potent Antimicrobials and Provide Insight into QAC Resistance
Garrison, M.A.#; Mahoney, A.R.#; Wuest, W.M.*
ChemMedChem 2020, 16 (3), 463-466
89Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumannii via Dysregulation of Heme Biosynthesis
Hübner, I.; Shapiro, J.A.; Hoßmann, J.; Drechsel, J.; Hacker, S.M.; Rather, P.N.; Pieper, D.H.; Wuest, W.M.; Sieber, S.A.*
ACS Cent. Sci. 2021, 7 (3), 488-498
88Antibacterials
Cheng Jaramillo, A.V.; Wuest, W.M.
American Chemical Society, 2021
(Invited contributor for ACS In-Focus Series of E-books)
87Synthesis and Biological Evaluation of an Antibacterial Azaborine Retinoid Isostere
Haney, B.A.; Schrank, C.L.; Wuest, W.M.*
Tetrahedron Lett. 2021, 62, 152667
(Invited Issue in Honor of Dale Boger)
86A Look Around the West Indies: The Spices of Life are Secondary Metabolites
Demeritte, A.; Wuest, W.M.*
Bioorg. Med. Chem. 2020, 28 (23), 115792
(Invited Review)
85Building trans-Bicyclo[4.4.0]decanes/decenes in Complex Multifunctional Frameworks: The Case for Antibiotic Development
Zhang, W.#; Kaplan, A.R.#; Davison, E.K.; Freeman, J.L.; Brimble, M.A.; Wuest, W.M.*
Nat. Prod. Rep. 2021, 38, 880-889
84Advancements in the Development of Non-Nitrogen-Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance
Carden, R.G.; Sommers, K.J.; Schrank, C.L.; Leitgeb, A.J.; Feliciano, J.A.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2020, 15 (21), 1974-1984
83The Histone-like Protein AlgP Regulon is Distinct in Mucoid and Nonmucoid Pseudomonas aeruginosa and Does Not Include Alginate Biosynthesis Genes
Cross, A.R.; Csatary, E.E.; Raghuram, V.; Diggle, F.L.; Whiteley, M.; Wuest, W.M.; Goldberg, J.B.*
Microbiology 2020, 166 (9), 861-866
82Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin
Davison, E.K.; Freeman, J.L.; Zhang, W.; Wuest, W.M.; Furkert, D.P.; Brimble, M.A.*
Org. Lett. 2020, 22 (14), 5550-5554
81Total Synthesis of (+)-Pilosinine via a Stereodivergent Conjugate Addition Strategy
Schrank, C.L.; Danneman, M.W.; Prebihalo, E.A.; Anderson, R.E.; Gibson, T.J.; Wuest, W.M.; Mullins, R.J.*
Tetrahedron Lett. 2020, 61 (23), 151945
80Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?
Schrank, C.L.; Minbiole, K.P.C.*; Wuest, W.M.*
ACS Infect. Dis. 2020, 6 (7), 1553-1557
(Over 40,000 views in a year)
78Addition of Ethylamines to the Phenols of Bithionol and Synthetic Retinoids Does Not Elicit Activity in Gram-Negative Bacteria
Cheng, A.V.#; Schrank, C.L.#; Escobar, I.E.; Mylonakis, E.; Wuest, W.M.*
Bioorg. Med. Chem. Lett. 2020, 30 (9), 127099
77Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase
Post, S.J.#; Keohane, C.E.#; Rossiter, L.M.; Kaplan, A.R.; Khowsathit, J.; Matuska, K.; Karanicolas, J.; Wuest, W.M.*
ACS Infect. Dis. 2020, 6 (6), 1372-1377
(Antibiotics Special Issue)
76Phylogeny-Guided Approach Yields Glycopeptides with Unique Action
Cheng, A.V.; Wuest, W.M.*
Trends in Pharmacological Sciences 2020, 41 (5), 297-299
(Invited Highlight)
75Broadening Activity of Polymyxin by Quaternary Ammonium Grafting
Ongwae, G.M.; Morrison, K.R.; Allen, R.A.; Kim, S.; Im, W.; Wuest, W.M.; Pires, M.M.*
ACS Infect. Dis. 2020, 6 (6), 1427-1435
(Antibiotics Special Issue)
74Virulence Attenuating Combination Therapy: A Potential Multi-Target Synergy Approach to Treat Pseudomonas aeruginosa Infections in Cystic Fibrosis Patients
Shaw, E.; Wuest, W.M.*
RSC Med. Chem. 2020, 11, 358-369
73Further Investigations into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics
Leitgeb, A.J.; Feliciano, J.A.; Sanchez, H.A.; Allen, R.A.; Morrison, K.R.; Sommers, K.J.; Carden, R.G.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2020, 15 (8), 667-670
(Selected for Cover Art)
72Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study
Alkhalifa, S.; Jennings, M.C.; Granata, D.; Klein, M.; Wuest, W.M.*; Minbiole, K.P.C.*; Carnevale, V.*
ChemBioChem 2019, 21 (10), 1510-1516
71Repurposing Human Kinase Inhibitors to Create an Antibiotic Active Against Drug-Resistant Staphylococcus aureus, Persisters and Biofilms
Le, P.; Kunold, E.; Macsics, R.; Rox, K.; Jennings, M.C.; Ugur, I.; Reinecke, M.; Chaves-Moreno, D.; Hackl, M.W.; Fetzer, C.; Mandl, F.A.M.; Lehmann, J.; Korotkov, V.S.; Hacker, S.M.; Kuster, B.; Antes, I.; Pieper, D.H.; Rohde, M.; Wuest, W.M.; Medina, E.; Sieber, S.A.*
Nat. Chem. 2020, 12, 145-158
70A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism
Ochoa, C.#; Solinski, A.E.#; Nowlan, M.; Dekarske, M.M.; Wuest, W.M.*; Kozlowski, M.C.*
ACS Infect. Dis. 2020, 6 (1), 74-79
69More QACs, More Questions: Recent Advances in Structure Activity Relationships and Hurdles in Understanding Resistance Mechanisms
Morrison, K.R.; Allen, R.A.; Minbiole, K.P.C.*; Wuest, W.M.*
Tetrahedron Lett. 2019, 60 (37), 150935
(Invited Digest)
67A Selective Membrane-Targeting Repurposed Antibiotic with Activity Against Persistent Methicillin-Resistant Staphylococcus aureus
Kim, W.; Zou, G.; Hari, T.P.A.; Wilt, I.K.; Zhu, W.; Galle, N.; Faizi, H.A.; Hendricks, G.L.; Tori. K.; Pan, W.; Huang, X.; Steele, A.D.; Csatary, E.E.; Dekarske, M.M.; Rosen, J.L.; de Queiroz Ribeiro, N.; Lee, K.; Port, J.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gao, H.; Ausubel, F.M.*; Mylonakis,E.*
Proc. Natl. Acad. Sci. U.S.A. 2019, 116 (33), 16529-16534
66Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids
Cheng, A.V.; Kim, W.; Escobar, I.E.; Mylonakis, E.; Wuest, W.M.*
ACS Med. Chem. Lett. 2020, 11 (3), 393-397
(Featured in the Women in Medicinal Chemistry Issue)
65Combined Inhibition of Aurora A and p21-Activated Kinase 1 as a New Treatment Strategy in Breast Cancer
Korobeynikov, V.; Borakove, M.; Feng, Y.; Wuest, W.M.; Koval, A.B.; Nikonova, A.S.; Serebriiskii, I.; Chernoff, J.; Borges, V.F.; Golemis, E.A.; Shagisultanova, E.*
Breast Cancer Research and Treatment 2019, 117, 369-382
64Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans
Solinski, A.E.; Scharnow, A.M.; Fraboni, A.J., Wuest, W.M.*
ACS Infect. Dis. 2019, 5 (8), 1480-1486
63Substituted Polycationic Multi-Quaternary Ammonium Salts as Antimicrobial Agents
Wuest, W.M.; Minbiole, K.P.C.
US10301254B2, 2019
62Hijacking the Bacterial Circuitry of Biofilm Processes via Chemical “Hot-Wiring”: An Under-explored Avenue for Therapeutic Development
Wilt, I.K.; Hari, T.P.A.; Wuest, W.M.*
ACS Infect. Dis. 2019, 5 (6), 789-795
(Invited Viewpoint)
61Signed, Sealed, Delivered: Conjugate and Prodrug Strategies as Targeted Delivery Vectors for Antibiotics
Cheng, A.V.; Wuest, W.M.*
ACS Infect. Dis. 2019, 5 (6), 816-828
60The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa
Zhao, W.; Cross, A.R.; Crowe-McAuliffe, C.; Weigert-Munoz, A.; Csatary, E.E.; Solinski, A.E.; Krysiak, J.; Goldberg, J.B.; Wilson, D.N.; Medina, E.; Wuest, W.M.; Sieber S.A.*
Angew. Chem. Int. Ed. 2019, 58 (25), 8581-8584
59Connecting Iron Acquisition and Biofilm Formation in the ESKAPE Pathogens as a Strategy for Combatting Antibiotic Resistance
Post, S.J.; Shapiro, J.A.; Wuest, W.M.*
MedChemComm 2019, 10, 505-512
(Invited Review for the Antibiotic Resistance Issue)
58Targeting S. mutans Biofilms: A Perspective on Preventing Dental Caries
Scharnow, A.M.; Solinski, A.E.; Wuest, W.M.*
MedChemComm 2019, 10, 1057-1067
(Invited Review for the New Talent Collection)
57Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space
Kearney, S.E.; Zahoránszky-Kőhalmi, G.; Brimacombe, K.R.; Henderson, M.J.; Lynch, C.; Zhao, T.; Wan, K.K.; Itkin, Z.; Dillon, C.; Shen, M.; Cheff, D.M.; Lee, T.D.; Bougie, D.; Cheng, K.; Coussens, N.P.; Dorjsuren, D.; Eastman, R.T.; Huang, R.; Iannotti, M.J.; Karavadhi, S.; Klumpp-Thomas, C.; Roth, J.S.; Sakamuru, S.; Sun, W.; Titus, S.A.; Yasgar, A.; Zhang, Y.-Q.; Zhao, J.; Andrade, R.B.; Brown, M.K.; Burns, N.Z.; Cha, J.K.; Mevers, E.E.; Clardy, J.; Clement, J.A.; Crooks, P.A.; Cuny, G.D.; Ganor, J.; Moreno, J.; Morrill, L.A.; Picazo, E.; Susick, R.B.; Garg, N.K.; Goess, B.C.; Grossman, R.B.; Hughes, C.C.; Johnston, J.N.; Joullie, M.M.; Kinghorn, A.D.; Kingston, D.G.I.; Krische, M.J.; Kwon, O.; Maimone, T.J.; Majumdar, S.; Maloney, K.N.; Mohamed, E.; Murphy, B.T.; Nagorny, P.; Olson, D.E.; Overman, L.E.; Brown, L.E.; Snyder, J.K.; Porco, J.A.; Rivas, F.; Ross, S.A.; Sarpong, R.; Sharma, I.; Shaw, J.T.; Xu, Z.; Shen, B.; Shi, W.; Stephenson, C.R.J.; Verano, A.L.; Tan, D.S.; Tang, Y.; Taylor, R.E.; Thomson, R.J.; Vosburg, D.A.; Wu, J.; Wuest, W.M.; Zakarian, A.; Zhang, Y.; Ren, T.; Zuo, Z.; Inglese, J.; Michael, S.; Simeonov, A.; Zheng, W.; Shinn, P.; Jadhav, A.; Boxer, M.B.; Hall, M.D.*; Xia, M.; Guha, R.; Rohde, J.M.*
ACS Cent. Sci. 2018, 4 (12), 1727-1741
55Influence of pH on the Reactions of Heme Peroxidase-Derived Oxidants with R19S
Kilgore, M.B.; Morrison, K.R.; Wuest, W.M.; Chandler, J.D.*
Free Radical Biology and Medicine 2018, 128 (1), S101-S102
54Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK)
Shapiro, J.A.; Varga, J.J.; Parsonage, D.; Walton, W.; Redinbo, M.R.; Ross, L.J.; White, E.L.; Bostwick, R.*; Wuest, W.M.*; Claiborne, A.*; Goldberg, J.B.*
ChemMedChem 2019, 14 (1), 78-82
53An Investigation into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics
Kontos, R.C.; Schallenhammer, S.A.; Bentley, B.S.; Morrison, K.R.; Feliciano, J.A.; Tasca, J.A.; Kaplan, A.R.; Bezpalko, M.W.; Kassel, W.S.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2019, 14 (1), 83-87
52Epoxy Isonitriles, A Unique Class of Antibiotics: Synthesis of Their Metabolites and Biological Investigations
Ernouf, G.; Wilt, I.K.; Zahim, S.; Wuest, W.M.*
ChemBioChem 2018, 19 (23), 2448-2452
(Selected for ChemBio Talents Issue)
51Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product
Shapiro, J.A.#; Morrison, K.R.#; Chodisetty, S.S.; Musaev, D.G.; Wuest, W.M.*
Org. Lett. 2018, 20 (18), 5922-5926
50Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters
Kim, W.; Steele, A.D.; Zhu, W.; Csatary, E.E.; Fricke, N.; Dekarske, M.M.; Jayamani, E.; Pan, W.; Kwon, B.; Sinitsa, I.F.; Rosen, J.L.; Conery, A.L.; Fuchs, B.B.; Vlahovska, P.M.; Ausubel, F.M.; Gao, H.; Wuest, W.M.*; Mylonakis, E.*
ACS Infect. Dis. 2018, 4 (11), 1540-1545
49From General to Specific: Can Pseudomonas Primary Metabolism Be Exploited for Narrow-Spectrum Antibiotics?
Shapiro, J.A.; Kaplan, A.R.; Wuest, W.M.*
ChemBioChem 2019, 20 (1), 34-39
(Invited Concept, Highlighted in the 20th Anniversary Issue)
48Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas putida KT2440
Giglio, K.M.#; Keohane, C.E.#; Stodghill, P.V.; Steele, A.D.; Fetzer, C.; Sieber, S.A.; Filiatrault, M.J.*; Wuest, W.M.*
ACS Infect. Dis. 2018, 4 (8), 1179-1187
47A New Class of Synthetic Retinoid Antibiotics Effective Against Bacterial Persisters
Kim, W.; Zhu, W.; Hendricks, G.L.; Van Tyne, D.; Steele, A.D.; Keohane, C.E.; Fricke, N.; Conery, A.L.; Shen, S.; Pan, W.; Lee, K.; Rajamuthiah, R.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gilmore, M.S.; Gao, H.; Ausubel, F.M.; Mylonakis, E.*
Nature 2018, 556, 103-107
46Claramines: A New Class of Broad-Spectrum Antimicrobial Agents With Bimodal Activity
Blanchet, M.; Borselli, D.; Rodallec, A.; Peiretti, F.; Vidal, N.; Bolla, J.-M.; Digiorgio, C.; Morrison, K.R.; Wuest, W.M.; Brunel, J.M.*
ChemMedChem 2018, 13 (10), 1018-1027
45Dual Inhibitor of Staphylococcus aureus Virulence and Biofilm Attenuates Expression of Major Toxins and Adhesins
Hofbauer, B.#; Vomacka, J.#; Stahl, M.; Korotkov, V.S.; Jennings, M.C.; Wuest, W.M.; Sieber, S.A.*
Biochemistry 2018, 57 (11), 1814-1820
44Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action
Steele, A.D.; Ernouf, G.; Lee, Y.-E.; Wuest, W.M.*
Org. Lett. 2018, 20 (4), 1126-1129
43Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase
Keohane, C.E.; Steele, A.D.; Fetzer, C.; Khowsathit, J.; Van Tyne, D.; Moynié, L.; Gilmore, M.S.; Karanicolas, J.; Sieber, S.A.; Wuest, W.M.*
J. Am. Chem. Soc. 2018, 140 (5), 1774-1782
42Polymeric Quaternary Ammonium Compounds: Versatile Antimicrobial Materials
Zubris, D.L.*; Minbiole, K.P.C.*; Wuest, W.M.*
Curr. Top. Med. Chem. 2017, 17 (3), 305-318
(Invited Review)
41Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria
Solinski, A.E.#; Ochoa, C.#; Lee, Y.-E.#; Paniak, T.; Kozlowski, M.C.*; Wuest, W.M.*
ACS Infect. Dis. 2018, 4 (2), 118-122
40Hybrid BisQACs: Potent Biscationic Quaternary Ammonium Compounds Merging the Structures of Two Commercial Antiseptics
Schallenhammer, S.A.; Duggan, S.M.; Morrison, K.R.; Bentley, B.S.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2017, 12 (23), 1931-1934
39EroS Enzyme from Aliivibrio fischeri Plays Cupid to Choanoflagellates
Rossiter, S.E.; Wuest, W.M.*
ChemBioChem 2017, 18 (23), 2298-2300
(Invited Highlight Article)
38Natural Products as Platforms to Overcome Antibiotic Resistance
Rossiter, S.E.; Fletcher, M.H.; Wuest, W.M.*
Chem. Rev. 2017, 117 (19), 12415-12474
36A Novel Application of the Staudinger Ligation to Access Neutral Cyclic Di-Nucleotide Analog Precursors via a Divergent Method
Fletcher, M.H.; Burns-Lynch, C.E.; Knouse, K.W.; Abraham, L.T.; DeBrosse, C.W.; Wuest, W.M.*
RSC Adv. 2017, 7, 29835-29838
35Efflux Pumps Might Not Be the Major Drivers of QAC Resistance in Methicillin-Resistant Staphylococcus aureus
Jennings, M.C.; Forman, M.E.; Duggan, S.M.; Minbiole, K.P.C.*; Wuest, W.M.*
ChemBioChem 2017, 18 (16), 1573-1577
(Highlighted as a Very Important Paper, Selected for Cover Art)
34Ester- and Amide-containing multiQACs: Exploring Multicationic Soft Antimicrobial Agents
Allen, R.A.; Jennings, M.C.; Mitchell, M.A.; Al-Khalifa, S.E.; Wuest, W.M.*; Minbiole, K.P.C.*
Bioorg. Med. Chem. Lett. 2017, 27 (10), 2107-2112
33Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms
Solinski, A.E.#; Koval, A.B.#; Brzozowski, R.S.#; Morrison, K.R.; Fraboni, A.J.; Carson, C.E.; Eshraghi, A.R.; Zhou, G.; Quivey, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest, W.M.*
J. Am. Chem. Soc. 2017, 139 (21), 7188-7191
32The Development of Next-Generation Pyridinium-Based multiQAC Antiseptics
Al-Khalifa, S.E.; Jennings, M.C.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2016, 12 (4), 280-283
31From Antimicrobial Activity to Mechanism of Resistance: The Multifaceted Role of Simple Quaternary Ammonium Compounds in Bacterial Eradication
Minbiole, K.P.C.*; Jennings, M.C.; Ator, L.E.; Black, J.W.; Grenier, M.C.; LaDow, J.E.; Caran, K.L.; Seifert, K.; Wuest, W.M.*
Tetrahedron 2016, 72 (25), 3559-3566
30Natural Product-Inspired Approaches to Combat Bacteria
Jennings, M.C.; Wuest, W.M.*
Tetrahedron 2016, 72 (25), 3547
(Editorial Preface for Tetrahedron Symposium-in-Print)
29Building a Better Quaternary Ammonium Compound (QAC): Branched Tetracationic Antiseptic Amphiphiles
Forman, M.E.; Jennings, M.C.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemMedChem 2016, 11 (13), 1401-1405
(Selected for Cover Art)
28Twelve-Membered Macrolactones: Privileged Scaffolds for the Development of New Therapeutics
Brzozowski, R.S.; Wuest, W.M.*
Chem. Biol. Drug Des. 2017, 89 (2), 169-191
(Invited Review)
27Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity
Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.*
J. Am. Chem. Soc. 2016, 138 (18), 5833-5836
26Structure-Resistance Relationships: Interrogating Antiseptic Resistance in Bacteria with Multicationic Quaternary Ammonium Dyes
Forman, M.E.; Fletcher, M.H.; Jennings, M.C.; Duggan, S.M.; Minbiole, K.P.C.*; Wuest, W.M.*
ChemMedChem 2016, 11 (9), 958-962
25The Enantioselective Synthesis and Biological Evaluation of Chimeric Promysalin Analogs Facilitated by Diverted Total Synthesis
Knouse, K.W.; Wuest, W.M.*
J. Antibiotics 2016, 69, 337-339
(Invited Paper in Honor of Amos B. Smith, III)
24An Optimized Synthesis of the Potent and Selective Pak1 Inhibitor FRAX-1036
Koval, A.B.; Wuest, W.M.*
Tetrahedron Lett. 2016, 57 (3), 449-451
23The Rhizosphere Microbiome: A Playground for Natural Product Chemists
Keohane, C.E.; Steele, A.D.; Wuest, W.M.*
Synlett 2015, 26 (20), 2739-2744
22Natural Product-Derived Quaternary Ammonium Compounds with Potent Antimicrobial Activity
Joyce, M.D.; Jennings, M.C.; Santiago, C.N.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.*
J. Antibiotics 2016, 69, 344-347
(Invited Paper in Honor of Amos B. Smith, III)
21Scaffold-Hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials
Mitchell, M.A.; Iannetta, A.A.; Jennings, M.C.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.*
ChemBioChem 2015, 16 (16), 2299-2303
(Highlighted as a Very Important Paper)
20Total Synthesis and Biological Investigation of (–)-Promysalin
Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.*
J. Am. Chem. Soc. 2015, 137 (23), 7314-7317
19Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus
Jennings, M.C.; Buttaro, B.A.; Minbiole, K.P.C.; Wuest, W.M.*
ACS Infect. Dis. 2015, 1 (7), 304-309
18Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance
Jennings, M.C.; Minbiole, K.P.C.; Wuest, W.M.*
ACS Infect. Dis. 2015, 1 (7), 288-303
(Most cited publication in ACS Infectious Diseases)
17Molecular Simulation of Conformational Pre-Organization in Cyclic RGD Peptides
Wakefield, A.E.; Wuest, W.M.; Voelz, V.A.*
J. Chem. Inf. Model. 2015, 55 (4), 806-813
16The Antimicrobial Activity of Mono-, Bis-, Tris-, and Tetracationic Amphiphiles Derived from Simple Polyamine Platforms
Paniak, T.J.; Jennings, M.C.; Shanahan, P.C.; Joyce, M.D.; Santiago, C.N.; Wuest, W.M.*; Minbiole, K.P.C.*
Bioorg. Med. Chem. Lett. 2014, 24 (24), 5824-5828
15Draining the Moat: Disrupting Bacterial Biofilms with Natural Products
Fletcher, M.H.; Jennings, M.C.; Wuest, W.M.*
Tetrahedron 2014, 70 (37), 6373-6383
(Invited Review)
14Synthesis of Cyclic Dimeric Methyl Morpholinoside – A Common Synthetic Precursor to Cyclic Dinucleotide Analogs
Kinzie, C.R.; Steele, A.D.; Pasciolla, S.M.; Wuest, W.M.*
Tetrahedron Lett. 2014, 55 (35), 4966-4968
13Biofilm-Eradicating Properties of Quaternary Ammonium Amphiphiles: Simple Mimics of Antimicrobial Peptides
Jennings, M.C.; Ator, L.E.; Paniak, T.J.; Minbiole, K.P.C.*; Wuest, W.M.*
ChemBioChem 2014, 15, 2211-2215
12Beyond Paraquats: Dialkyl 3,3′- and 3,4′-Bipyridinium Amphiphiles as Antibacterial Agents
Ator, L.E.; Jennings, M.C.; McGettigan, A.R.; Paul, J.J.; Wuest, W.M.*; Minbiole, K.P.C.*
Bioorg. Med. Chem. Lett. 2014, 24, 3706-3709
11Using Technology to Create an Active, Collaborative Learning Environment: Even in Organic Chemistry!
Wuest, W.M.*; Wuest, L.M.*
Proceedings of the 2014 Lilly International Conference on College and University Teaching and Learning 2014, 44
10Computational Screening and Selection of Cyclic Peptide Hairpin Mimetics by Molecular Simulation and Kinetic Network Models
Razavi, A. M.; Wuest, W.M.*; Voelz, V.A.*
J. Chem. Inf. Model. 2014, 54 (5), 1425-1432
9A Concise Synthesis of Carolacton
Hallside, M.S.; Brzozowski, R.S.; Wuest, W.M.*; Phillips, A.J.*
Org. Lett. 2014, 16 (4), 1148-1151
(Top 10 Downloaded Publication in Organic Letters between January-June 2014)
8TMEDA-derived biscationic amphiphiles: An economical preparation of potent antibacterial agents
Black, J.W.; Jennings, M.C.; Azarewicz, J.; Paniak, T.J.; Grenier, M.C.; Wuest, W.M.*; Minbiole, K.P.C.*
Bioorg. Med. Chem. Lett. 2014, 24, 99-102
7Enzymatic Timing and Tailoring of Macrolactamization in Syringolin Biosynthesis
Wuest, W.M.; Krahn, D.; Kaiser, M.; Walsh, C.T.*
Org. Lett. 2011, 13 (17), 4518-4521
6SylC Catalyzes Ureido-Bond Formation During Biosynthesis of the Proteasome Inhibitor Syringolin A
Imker, H.J.; Walsh, C.T.*; Wuest, W.M.
J. Am. Chem. Soc. 2009, 131 (51), 18263-18265
5Three Siderophores from One Bacterial Enzymatic Assembly Line
Wuest, W.M.; Sattely, E.S.; Walsh, C.T.*
J. Am. Chem. Soc. 2009, 131 (14), 5056-5057
4Total Synthesis of (–)-2-epi-Peloruside A
Smith III, A.B.*; Cox, J.M.; Furuichi, N.; Kenesky, C.S.; Zheng, J.; Atasoylu, O.; Wuest, W.M.
Org. Lett. 2008, 10 (24), 5501-5504
3Evolution of Multi-Component Anion Relay Chemistry (ARC): Construction of Architecturally Complex Natural and Unnatural Products
Smith III, A.B.*; Wuest, W.M.
Chem. Commun. 2008, 5883-5895
2Ortho-TMS Benzaldehyde: An Effective Linchpin for Type II Anion Relay Chemistry (ARC)
Smith, A.B.*; Kim, W.-S.; Wuest, W.M.
Angew. Chem. Int. Ed. 2008, 47 (37), 7082-7086
1Intramolecular Hydroamination of Aminoalkynes with Silver Phenanthroline Catalysts
Carney, J.M.; Donoghue, P.J.; Wuest, W.M.; Wiest, O.; Helquist, P.*
Org. Lett. 2008, 10 (17), 3903-3906