1. In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe

Amber M. Scharnow, Amy E. Solinski, Sebastian Rowe, Ines Drechsel, Hua Zhang, Elana Shaw, Julia E. Page, Hui Wu, Stephan A. Sieber, William M. Wuest*

J. Am. Chem. Soc. 2024, 146, 23449–23456

2. Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold

Shapiro, J.A.; Post, S.J.; Smith, G.C.; Wuest, W.M.*

Org. Lett. 2023, 25, 9243-9248

3. Synthetic simplification of carolacton enables identification of a biofilm target in Streptococcus mutans via chemical genetics

Solinski, A.E.; Scharnow, A.M.; Wuest, W.M.*

ACS Infect. Dis. 2019, 5, 1480

4. Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase

Keohane, C.E.; Steele, A.D.; Fetzer, C.; Moynie, L.; Khowsathit, J.; Van Tyne, D.; Gilmore, M.S.; Karanicolas J.; Sieber, S.A.; Wuest, W.M.*

J. Am. Chem. Soc. 2018, 140, 1174.

5. Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action

Steele, A.D.; Ernouf, G.; Lee, Y-E.; Wuest, W.M.*

Org. Lett. 2018, 20, 1126.

6. Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms

Solinski, A.E.; Koval, A.B.; Brzozowski, R.B.; Morrison, K.R.; Fraboni, A.J.; Carson, C.E.; Eshraghi, A.R.; Zhou, G.; Quivey, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest, W.M.*

J. Am. Chem. Soc. 2017, 139, 7188.

7. Diverted Total Synthesis of Promysalin Analogs Demonstrates that an Iron-Binding Motif is Responsible for its Narrow-Spectrum Antibacterial Activity

Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.*

J. Am. Chem. Soc. 2016, 138, 5833.

8. Total Synthesis and Biological Investigation of (-)-Promysalin.

Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.*

J. Am. Chem. Soc. 2015, 137, 7314.

9. A Concise Synthesis of Carolacton

Hallside, M.S.; Brzozowski, R.S.; Wuest, W.M.; Phillips, A.J.

Org. Lett. 2014, 16, 1148. (Top 10 Downloaded Publication in Org. Lett. between Jan.-Jun 2014)

1. Repurposing a drug to punish carbapenem-resistant Acinetobacter baumannii

Colquhoun, J.M., Brzezinski, C.U., Ji, A., Marotta, J., Elsen, F.A., Bonomo, R.A., May, K.L., Sieber, S.A., Grabowicz, M., Wuest, W.M. and Rather, P.N.

Proc. Natl. Acad. Sci., 2025, 122, p.e2423650122.

2. Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms

Le, P.; Kunold, E.; Macsics, R.; Rox, K.; Jennings, M.C.; Ugur, I.; Reinecke, M.; Chaves-Moreno, D.; Hackl, M.W.; Fetzer, C.; Mandl, F.A.M.; Lehmann, J.; Korotkov, V.S.; Hacker, S.M.; Kuster, B.; Antes, I.; Pieper, D.H.; Rohde, M.; Wuest, W.M.; Medina, E.; Sieber, S.A.*

Nat. Chem. 2020, 12, 145

3. A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus

Kim, W.; Zou, G.; Hari, T.P.A.; Wilt, I.K.; Zhu, W.; Galle, N.; Faizi, H.A.; Hendricks, G.L.; Tori. K.; Pan, W.; Huang, X.; Steele, A.D.; Csatary, E.E.; Dekarske, M.M.; Rosen, J.L.; de Queiroz Ribiero, N.; Lee, K.; Port, J.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gao, H.; Ausubel, F.M.; Mylonakis,E.

Proc. Nat. Acad. Sci. 2019, 116, 16529 (Featured on NPR)

4. The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa

Zhao, W.; Cross, A.R.; Crowe-McAuliffe, C.; Weigert-Munoz, A.; Csatary, E.E.; Solinski, A.E.; Krysiak, J.; Goldberg, J.B.; Wilson, D.N.; Medina, E.; Wuest, W.M.; Sieber S.A.*

Angew. Chem. Int. Ed. 2019, 58, 8581

5. A new class of synthetic retinoid antibiotics effective against bacterial persisters

Kim, W.; Hendricks, G.; Zhu, W.; Van Tyne, D.; Steele, A.D.; Keohane, C.; Fricke, N.; Conery, A.L.; Shen, S.; Rahamuthiah, R.; Burgwyn Fuchs, B.; Vlahovska, P.M.; Wuest, W.M.; Gilmore, M.S.; Gao, H.; Ausubel, F.M.; Mylonakis, E.*

Nature 2018, 556, 103.

6. Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters

Kim, W.; Zhu, W.; Steele, A.D.; Zhu, W.; Csatary, E.E.; Fricke, N.; Dekarske, M.M.; Jayamani, E.; Pan, W.; Kwon, B.; Sinitsa, I.F.; Rosen, J.L.; Conery, A.L.; Fuchs, B.B.; Vlahovska, P.M.; Ausubel, F.M.; Gao, H.; Wuest, W.M., Mylonakis, E.

ACS Infect. Dis. 2018, 4, 1540.

1. Highly Effective Biocides against Pseudomonas aeruginosa Reveal New Mechanistic Insights Across Gram-Negative Bacteria

Christian A Sanchez, Germán G Vargas-Cuebas, Marina E Michaud, Ryan A Allen, Kelly R Morrison-Lewis, Shehreen Siddiqui, Kevin PC Minbiole, William M Wuest

ACS Infect. Dis. 2024, 10, 3868–3879

2. SoftQPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents

Brayton, S.R.; Toles, Z.E.A.; Sanchez, C.A.; Michaud, M.E.; Thierer, L.M.; Keller, T.M.; Risener, C.J.; Quave, C.L. Wuest, W.M.; Minbiole, K.P.C.

ACS Infect. Dis. 2023, 9, 943-951

3. Atom Economical QPCs: Phenyl-free Biscationic Quaternary Phosphonium Compounds as Potent Disinfectants

Thierer, L.M.; Peterson, A.A.; Michaud, M.E.; Sanchez, C.A.; Brayton, S.; Wuest, W.M.; Minbiole, K.P.C.

ACS Infect. Dis. 2023, 9, 609-616.

4. Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant Acinetobacter baumannii Clinical Isolates

Michaud, M.E.; Allen, R.A.; Morrison-Lewis. K.R.; Sanchez, C.A.; Minbiole, K.P.C.; Post, S.J.; Wuest, W.M.*

ACS Infect. Dis. 2022, 8, 2307-2314

5. Quaternary Phosphonium Compounds: An Examination of Non-nitrogenous Cationic Amphiphiles to Evade Disinfectant Resistanc

Sommers, K.J.#; Michaud, M.E.#; Hogue, C.E.; Scharnow, A.M.; Amoo, L.E.; Peterson, A.A.; Carden, R.G.; Minbiole, K.P.C.; Wuest, W.M.

ACS Infect. Dis. 2022, 8, 387–397 (Highlighted in C&E News)

6. Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study

Al-Khalifa, S.; Jennings, M.C.; Granata, D.; Klein, M.; Wuest, W.M., Minbiole, K.P.C., Carnevale, V.*

ChemBioChem 2020, 21, 1510.

7. Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus.

Al-Khalifa, S.; Jennings, M.C.; Granata, D.; Klein, M.; Wuest, W.M., Minbiole, K.P.C., Carnevale, V.*

ChemBioChem 2020, 21, 1510.

1. Siderophores: A Case Study in Translational Chemical Biology

LeBlanc, A.R.; Wuest, W.M.*

Biochemistry 2024, 15, 1877-1891.

2. Antibacterials

Cheng, A. V.; Wuest, W.M.

2021 DOI: 10.1021/acs.infocus.7e4006 (Invited contributor for ACS In-Focus Series of E-books)

3. The Silent Pandemic: Emergent Antibiotic Resistances Following the Global Response to SARS-CoV 2

Mahoney, A.R.; Safaee, M.M.; Wuest, W.M.; Furst, A.L.*

iScience 2021, 24, 102304 DOI: 10.1016/j.isci.2021.102304

4. Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?

Schrank, C.L.; Minbiole, K.P.C.; Wuest, W.M.

ACS Infect. Dis. 2020, 6, 1553 DOI: 10.1021/acsinfecdis.0c00265

5. Natural Products as Platforms to Overcome Antibiotic Resistance

Rossiter, S.E.; Fletcher, M.H.; Wuest, W.M.*

Chem. Rev. 2017, 117, 12415.

6. Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance

Jennings, M.C.; Minbiole, K.P.C.; Wuest, W.M.*

ACS Infect. Dis. 2015, 1, 288. (Most cited publication in ACS Infect. Dis.)